Erratic and blood vessel-guided migration of astrocyte progenitors in the cerebral cortex

Hidenori Tabata; Megumi Sasaki; Masakazu Agetsuma; Hitomi Sano; Yuki Hirota; Michio Miyajima; Kanehiro Hayashi; Takao Honda; Masashi Nishikawa; Yutaka Inaguma; Hidenori Ito; Hirohide Takebayashi; Masatsugu Ema; Kazuhiro Ikenaka; Junichi Nabekura; Koh-ichi Nagata; Kazunori Nakajima

doi:10.1038/s41467-022-34184-x

Nature Communications (Nov 2022)

Erratic and blood vessel-guided migration of astrocyte progenitors in the cerebral cortex

Hidenori Tabata,
Megumi Sasaki,
Masakazu Agetsuma,
Hitomi Sano,
Yuki Hirota,
Michio Miyajima,
Kanehiro Hayashi,
Takao Honda,
Masashi Nishikawa,
Yutaka Inaguma,
Hidenori Ito,
Hirohide Takebayashi,
Masatsugu Ema,
Kazuhiro Ikenaka,
Junichi Nabekura,
Koh-ichi Nagata,
Kazunori Nakajima

Affiliations

Hidenori Tabata: Department of Molecular Neurobiology, Institute for Developmental Research, Aichi Developmental Disability Center
Megumi Sasaki: Department of Anatomy, Keio University School of Medicine
Masakazu Agetsuma: Division of Homeostatic Development, National Institute for Physiological Sciences
Hitomi Sano: Department of Anatomy, Keio University School of Medicine
Yuki Hirota: Department of Anatomy, Keio University School of Medicine
Michio Miyajima: Department of Anatomy, Keio University School of Medicine
Kanehiro Hayashi: Department of Anatomy, Keio University School of Medicine
Takao Honda: Department of Anatomy, Keio University School of Medicine
Masashi Nishikawa: Department of Molecular Neurobiology, Institute for Developmental Research, Aichi Developmental Disability Center
Yutaka Inaguma: Department of Molecular Neurobiology, Institute for Developmental Research, Aichi Developmental Disability Center
Hidenori Ito: Department of Molecular Neurobiology, Institute for Developmental Research, Aichi Developmental Disability Center
Hirohide Takebayashi: Division of Neurobiology and Anatomy, Graduate School of Medical and Dental Sciences, Niigata University
Masatsugu Ema: Department of Stem Cells and Human Disease Models, Research Center for Animal Life Science, Shiga University of Medical Science
Kazuhiro Ikenaka: Division of Neurobiology and Bioinformatics, National Institute for Physiological Sciences
Junichi Nabekura: Division of Homeostatic Development, National Institute for Physiological Sciences
Koh-ichi Nagata: Department of Molecular Neurobiology, Institute for Developmental Research, Aichi Developmental Disability Center
Kazunori Nakajima: Department of Anatomy, Keio University School of Medicine

DOI: https://doi.org/10.1038/s41467-022-34184-x
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 21

Abstract

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During development, astrocytes are generated from radial glia, and migrate to the cortical plate, but the process of astrocyte migration during development is not fully understood. Here the authors labelled cells derived from the cortical ventricular zone in the late stages of cortical plate development in mice, and identified a migration mode in which cells move rapidly and almost at random within the intermediate zone and the cortical plate.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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