The role of epicardial and pericoronary adipose tissue radiomics in identifying patients with non-ST-segment elevation myocardial infarction from unstable angina

Abstract

Objectives: This study aimed to ascertain if the radiomics features of epicardial adipose tissue (EAT) and pericoronary adipose tissue (PCAT) based on coronary computed tomography angiography (CCTA) could identify non-ST-segment elevation myocardial infarction (NSTEMI) from unstable angina (UA). Materials and methods: This retrospective case-control study included 108 patients with NSTEMI and 108 controls with UA. All patients were separated into training cohort (n = 116), internal validation cohort 1 (n = 50), and internal validation cohort 2 (n = 50) based on the time order of admission. The internal validation cohort 1 used the same scanner and scan parameters as the training cohort, while the internal validation cohort 2 used different canners and scan parameters than the training cohort. The EAT and PCAT radiomics features selected by maximum relevance minimum redundancy (mRMR) and least absolute shrinkage and selection operator (LASSO) were adopted to build logistic regression models. Finally, we developed an EAT radiomics model, three vessel-based (right coronary artery [RCA], left anterior descending artery [LAD], and left circumflex artery [LCX]) PCAT radiomics models, and a combined model by combining the three PCAT radiomics models. Discrimination, calibration, and clinical application were employed to assess the performance of all models. Results: Eight radiomics features of EAT, sixteen of RCA-PCAT, fifteen of LAD-PCAT, and eighteen of LCX-PCAT were selected and used to construct radiomics models. The area under the curves (AUCs) of the EAT, RCA-PCAT, LAD-PCAT, LCX-PCAT and the combined models were 0.708 (95% CI: 0.614–0.802), 0.833 (95% CI:0.759–0.906), 0.720 (95% CI:0.628–0.813), 0.713 (95% CI:0.619–0.807), 0.889 (95% CI:0.832–0.946) in the training cohort, 0.693 (95% CI:0.546–0.840), 0.837 (95% CI: 0.729–0.945), 0.766 (95% CI: 0.625–0.907), 0.675 (95% CI: 0.521–0.829), 0.898 (95% CI: 0.802–0.993) in the internal validation cohort 1, and 0.691 (0.535–0.847), 0.822 (0.701–0.944), 0.760 (0.621–0.899), 0.674 (0.517–0.830), 0.866 (0.769–0.963) in the internal validation cohort 2, respectively. Conclusion: Compared with the RCA-PCAT radiomics model, the EAT radiomics model had a limited ability to discriminate between NSTEMI and UA. The combination of the three vessel-based PCAT radiomics may have the potential to distinguish between NSTEMI and UA.

Keywords

• Radiomics
• Adipose tissue
• Myocardial infarction
• Unstable angina
• Coronary computed tomography angiography