A concise summary of powder processing methodologies for flow enhancement
Devanshi S. Shah,
Kailas K. Moravkar,
Durgesh K. Jha,
Vijay Lonkar,
Purnima D. Amin,
Shailesh S. Chalikwar
Affiliations
Devanshi S. Shah
Department of Pharmaceutical Sciences and Technology, Institute of Chemical Technology, Mumbai, India
Kailas K. Moravkar
Department of Industrial Pharmacy and Quality Assurance, R. C. Patel Institute of Pharmaceutical Education and Research, Karwand Naka, Shirpur, Dhule 425405, India; Regeron INC 103 BIO-2, Chuncheon BioTown, Chuncheon, South Korea; Corresponding author.
Durgesh K. Jha
Department of Pharmaceutical Sciences and Technology, Institute of Chemical Technology, Mumbai, India; DelNova Healthcare, An Innovation Center of ViRACS Healthcare, Thane, India
Vijay Lonkar
Department of Industrial Pharmacy and Quality Assurance, R. C. Patel Institute of Pharmaceutical Education and Research, Karwand Naka, Shirpur, Dhule 425405, India
Purnima D. Amin
Department of Pharmaceutical Sciences and Technology, Institute of Chemical Technology, Mumbai, India; Corresponding author.
Shailesh S. Chalikwar
Department of Industrial Pharmacy and Quality Assurance, R. C. Patel Institute of Pharmaceutical Education and Research, Karwand Naka, Shirpur, Dhule 425405, India; Corresponding author.
The knowledge of powder properties has been highlighted since the 19th century since most formulations focus on solid dosage forms, and powder flow is essential for various manufacturing operations. A poor powder flow may generate problems in the manufacturing processes and cause the plant's malfunction. Hence these problems should be studied and rectified beforehand by various powder flow techniques to improve and enhance powder flowability. The powder's physical properties can be determined using compendial and non-compendial methods. The non-compendial practices generally describe the powder response under the stress and shear experienced during their processing. The primary interest of the current report is to summarize the flow problems and enlist the techniques to eliminate the issues associated with the powder's flow properties, thereby increasing plant output and minimizing the production process inconvenience with excellent efficiency. In this review, we discuss powder flow and its measurement techniques and mainly focus on various approaches to improve the cohesive powder flow property.
