The Korean Journal of Helicobacter and Upper Gastrointestinal Research (Dec 2023)

Comparison of Eradication Rates Using Standard Triple Therapy and Sequential Therapy

  • Yuri Kim,
  • Ji Yong Ahn,
  • Hwoon-Yong Jung,
  • Jin Hee Noh,
  • Hee Kyong Na,
  • Kee Wook Jung,
  • Jeong Hoon Lee,
  • Do Hoon Kim,
  • Kee Don Choi,
  • Ho June Song,
  • Gin Hyug Lee

DOI
https://doi.org/10.7704/kjhugr.2023.0042
Journal volume & issue
Vol. 23, no. 4
pp. 277 – 282

Abstract

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Objectives The incidence of treatment failures following standard triple therapy (STT) for Helicobacter pylori eradication (HPE) has reached an unacceptable level. Sequential therapy (SQ) has emerged as a promising approach to counteract the escalation of antibiotic resistance. In this study, we used a chronological cohort dataset to conduct a comparative analysis of the eradication rates, compliance, and adverse events associated with the 7-day STT and SQ. Methods A total of 789 patients underwent HPE treatment at Asan Medical Center between July 2013 and August 2017. Among them, 378 received a 7-day STT and 411 received a 10-day SQ. Baseline clinical data and treatment parameters were compared between the two treatment groups. Results SQ demonstrated an eradication rate of 84.7% (348/411), which was superior to that of the 7-day STT (74.1%; p<0.001). The incidence of adverse events was also higher in the SQ group than in the STT group (17.5% vs. 11.1%; p=0.01). Nonetheless, treatment compliance was not significantly different between the groups (98.1% [SQ] vs. 96.8% [STT]; p=0.38). Among the patients undergoing second-line eradication, the SQ group displayed a lower eradication rate than the STT group (77.8% vs. 92.4%; p=0.028). Notably, the overall eradication rate did not differ significantly between the two groups (98.3% [STT] vs. 97.4% [SQ]; p=0.56). Conclusions SQ exhibited superior efficacy compared with the 7-day STT as a first-line H. pylori treatment. Thus, SQ holds potential to serve as the replacement for the 7-day STT in treatment-naïve patients.

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