Nature Communications (Jul 2020)

A genome-wide cross-phenotype meta-analysis of the association of blood pressure with migraine

  • Yanjun Guo,
  • Pamela M. Rist,
  • Iyas Daghlas,
  • Franco Giulianini,
  • The International Headache Genetics Consortium,
  • The 23andMe Research Team,
  • Tobias Kurth,
  • Daniel I. Chasman

DOI
https://doi.org/10.1038/s41467-020-17002-0
Journal volume & issue
Vol. 11, no. 1
pp. 1 – 11

Abstract

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The association between blood pressure (BP) and migraine is poorly understood. Here, the authors explore this relationship using summary-level GWAS data for BP and migraine. Cross-trait meta-analysis reveals shared loci between BP and migraine, while Mendelian randomization suggests that diastolic BP specifically plays a key role in migraine susceptibility.