Patient-derived tumor organoids for personalized medicine in a patient with rare hepatocellular carcinoma with neuroendocrine differentiation: a case report

Marie-Anne Meier; Sandro Nuciforo; Mairene Coto-Llerena; John Gallon; Matthias S. Matter; Caner Ercan; Jürg Vosbeck; Luigi M. Terracciano; Savas D. Soysal; Daniel Boll; Otto Kollmar; Raphaël Delaloye; Salvatore Piscuoglio; Markus H. Heim

doi:10.1038/s43856-022-00150-3

Communications Medicine (Jul 2022)

Patient-derived tumor organoids for personalized medicine in a patient with rare hepatocellular carcinoma with neuroendocrine differentiation: a case report

Marie-Anne Meier,
Sandro Nuciforo,
Mairene Coto-Llerena,
John Gallon,
Matthias S. Matter,
Caner Ercan,
Jürg Vosbeck,
Luigi M. Terracciano,
Savas D. Soysal,
Daniel Boll,
Otto Kollmar,
Raphaël Delaloye,
Salvatore Piscuoglio,
Markus H. Heim

Affiliations

Marie-Anne Meier: Department of Biomedicine, University Hospital and University of Basel
Sandro Nuciforo: Department of Biomedicine, University Hospital and University of Basel
Mairene Coto-Llerena: Department of Biomedicine, University Hospital and University of Basel
John Gallon: Department of Biomedicine, University Hospital and University of Basel
Matthias S. Matter: Institute of Medical Genetics and Pathology, University Hospital Basel
Caner Ercan: Institute of Medical Genetics and Pathology, University Hospital Basel
Jürg Vosbeck: Institute of Medical Genetics and Pathology, University Hospital Basel
Luigi M. Terracciano: Department of Anatomic Pathology, IRCCS Humanitas Research Hospital, Rozzano
Savas D. Soysal: Clarunis University Center for Gastrointestinal and Liver Diseases
Daniel Boll: Radiology and Nuclear Medicine, University Hospital Basel
Otto Kollmar: Clarunis University Center for Gastrointestinal and Liver Diseases
Raphaël Delaloye: Department of Oncology, University Hospital Basel
Salvatore Piscuoglio: Department of Biomedicine, University Hospital and University of Basel
Markus H. Heim: Department of Biomedicine, University Hospital and University of Basel

DOI: https://doi.org/10.1038/s43856-022-00150-3
Journal volume & issue: Vol. 2, no. 1
pp. 1 – 8

Abstract

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Meier, Nuciforo, Coto-Llerena et al. report a rare case of a patient with hepatocellular carcinoma with neuroendocrine differentiation. The authors establish organoids that recapitulate the genetic features of the patient’s tumor and are used for ex vivo drug testing to guide therapy selection in the patient.

Published in Communications Medicine

ISSN: 2730-664X (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Medicine
Website: https://www.nature.com/commsmed/

About the journal