Pharmacological and Diagnostic Research Center, Faculty of Pharmacy, Al-Ahliyya Amman University, Amman 19328, Jordan
Dima Khater
Department of Chemistry, Faculty of Arts and Science, Applied Science Private University, Amman 11931, Jordan
Fadwa Odeh
Department of Chemistry, The University of Jordan, Amman 11942, Jordan; Corresponding author.
Fedaa Al-Adaileh
Department of Chemistry, The University of Jordan, Amman 11942, Jordan
Suma Al-Taher
Department of Chemistry, The University of Jordan, Amman 11942, Jordan
Areej M. Jaber
Pharmacological and Diagnostic Research Center, Faculty of Pharmacy, Al-Ahliyya Amman University, Amman 19328, Jordan
Walhan Alshaer
Cell Therapy Center, The University of Jordan, Amman 11942, Jordan
Abeer Al Bawab
Department of Chemistry, The University of Jordan, Amman 11942, Jordan; Hamdi Mango Center for Scientific Research, The University of Jordan, Amman 11942, Jordan
Mohammad S. Mubarak
Department of Chemistry, The University of Jordan, Amman 11942, Jordan; Corresponding author.
Advancements in both material science and bionanotechnology are transforming the health care sector. To this end, nanoparticles are increasingly used to improve diagnosis, monitoring, and therapy. Huge research is being carried out to improve the design, efficiency, and performance of these nanoparticles. Nanoparticles are also considered as a major area of research and development to meet the essential requirements for use in nanomedicine where safety, compatibility, biodegradability, biodistribution, stability, and effectiveness are requirements towards the desired application. In this regard, lipids have been used in pharmaceuticals and medical formulations for a long time. The present work focuses on the use of lipid nanostructures to combat brain tumors. In addition, this review summarizes the literature pertaining to solid lipid nanoparticles (SLN) and nanostructured lipid carriers (LNC), methods of preparation and characterization, developments achieved to overcome blood brain barrier (BBB), and modifications used to increase their effectiveness.
