Chinese Journal of Physiology (Jan 2021)

Response of heart rate variability and cardiorespiratory phase synchronization to routine bronchodilator test in patients with asthma

  • Chih-Hsiang Tsou,
  • Lin-Sen Pon,
  • Jun-Zhi Liang,
  • Yun-Hsiang Chan,
  • Kuan-Jung Chen,
  • Feng-Shiang Cheng,
  • Tsair Kao,
  • Sai-Wei Yang

DOI
https://doi.org/10.4103/cjp.cjp_19_21
Journal volume & issue
Vol. 64, no. 4
pp. 177 – 185

Abstract

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Heart rate variability (HRV) and cardiorespiratory phase synchronization (CRPS) were employed to study the cardio- and respiratory interactions in patients with asthma receiving inhalation of beta2-agonist (Berotec 200 mcg) for routine bronchodilator test. Both time- and frequency-domain parameters were used to analyze the HRV. A weighted G-index was introduced to study the quality of the CRPS. The HRV parameters, in both the time and frequency domains, exhibited significant changes pointing to a sympathetic activation of the autonomic balance immediately after the inhalation. On the other hand, the CRPS index barely changed throughout the entire process. This indicates that inhalation of beta2-agonist does not alter the CRPS appreciably, and that the CRPS, in contrast to HRV, is relatively stable in response to the inhalation of beta2-agonist in patients with asthma.

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