Медицинская иммунология (Jul 2014)

CYTOKINE PROFILE OF TH1- AND TH2-DEPENDENT VARIANTS OF CHRONIC GVHD

  • O. T. Kudaeva,
  • V. O. Tkachev,
  • E. D. Gavrilova,
  • E. V. Goiman,
  • N. N. Volsky,
  • O. M. Perminova,
  • O. P. Kolesnikova

DOI
https://doi.org/10.15789/1563-0625-2012-1-2-67-74
Journal volume & issue
Vol. 14, no. 1-2
pp. 67 – 74

Abstract

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Abstract. Induction of chronic GVHD in the DBA/2→(C57Bl/6xDBA/2) F1 semi-allogeneic murine model results into development of Th1- and Th2-dependent immunopathological conditions that are characterized by different cytokine profiles. Chronic GVHD is accompanied by a sharp increase in IgE levels, thus presuming considerable IL-4 production. In recipients with Th2-dependent GvHD variant, elevated contents of serum IL-6, IL-7 and TNFα were also observed, which, along with other effects, may support polyclonal activation of B cells, thus leading to development of autoimmune pathology.

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