ASSOCIATIONS OF BLOOD GROUPS ANTIGENS OF AB0 AND RHESUS SYSTEMS WITH THE DEVELOPMENT OF CHRONIC KIDNEY DISEASE, GLOMERULONEPHRITIS

Abstract

Introduction. Finding of biological markers of genetic predisposition to the formation of glomerulonephritis (GN) will promote prediction the probability of its development still at an early stage and provide the growth of preventive direction of medicine. The purpose of the study is to evaluate the risk of GN development by antigens of AB0 and rhesus (Rh) blood groups. Materials and methods. The study included 434patients with GN(242M, 192F, aged 37.56 ± 13.01y). 1428 healthy persons was surveyed to determine the distribution of phenotypes of AB0 and Rh blood groups in the population. Results. The total value of the relative risk of GN development in all Rh–negative carriers ABprevailed by 2.34 times in the same Rh–positive. The total value of the relative risk of disease appearance in Rh–negative individuals prevailed in the same Rh–positive according to gender: in men with A and AB – 6.43 and 4.16 times, respectively, in women with B and AB – 9.34 and 2.15 times, respectively. In all patients, the common feature was a high chance of getting sick by GN in carriers phenotype AB Rh– versus 0 Rh–. Conclusions. The sex dimorphism of hereditary predisposition markers for GN is proved: men with phenotypes A Rh– and AB Rh–, women with B Rh–, AB Rh– and AB Rh+ have high risk to be ill. The persons of both sexes with phenotype 0 Rh–, as well as men with B Rh– and women with A Rh– and B Rh+ may be resistant to disease.

Keywords

• chronic kidney disease, glomerulonephritis, blood group, AB0 system, Rhesus, erythrocytic antigens.