mBio
(Feb 2021)
Discovery of Bacterial Fimbria–Glycan Interactions Using Whole-Cell Recombinant Escherichia coli Expression
Christopher J. Day,
Alvin W. Lo,
Lauren E. Hartley-Tassell,
M. Pilar Argente,
Jessica Poole,
Nathan P. King,
Joe Tiralongo,
Michael P. Jennings,
Mark A. Schembri
Affiliations
Christopher J. Day
Institute for Glycomics, Griffith University, Gold Coast, Queensland, Australia
Alvin W. Lo
School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, Australia
Lauren E. Hartley-Tassell
Institute for Glycomics, Griffith University, Gold Coast, Queensland, Australia
M. Pilar Argente
Institute for Glycomics, Griffith University, Gold Coast, Queensland, Australia
Jessica Poole
Institute for Glycomics, Griffith University, Gold Coast, Queensland, Australia
Nathan P. King
School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, Australia
Joe Tiralongo
Institute for Glycomics, Griffith University, Gold Coast, Queensland, Australia
Michael P. Jennings
ORCiD Institute for Glycomics, Griffith University, Gold Coast, Queensland, Australia
Mark A. Schembri
ORCiD School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, Australia
DOI
https://doi.org/10.1128/mBio.03664-20
Journal volume & issue
Vol. 12,
no. 1
Abstract
Read online
Understanding the tropism of pathogens for host and tissue requires a complete understanding of the host receptors targeted by fimbrial adhesins. Furthermore, blocking adhesion is a promising strategy to counter increasing antibiotic resistance and is enabled by the identification of host receptors.
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