Nature Communications (Oct 2018)

Large-scale genome-wide enrichment analyses identify new trait-associated genes and pathways across 31 human phenotypes

  • Xiang Zhu,
  • Matthew Stephens

DOI
https://doi.org/10.1038/s41467-018-06805-x
Journal volume & issue
Vol. 9, no. 1
pp. 1 – 14

Abstract

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In genome-wide association studies, variant-level associations are hard to identify and can be difficult to interpret biologically. Here, the authors develop a new model-based enrichment analysis method, and apply it to identify new associated genes, pathways and tissues across 31 human phenotypes.