Communications Biology (Sep 2021)

Prenylcysteine oxidase 1, an emerging player in atherosclerosis

  • C. Banfi,
  • R. Baetta,
  • S. S. Barbieri,
  • M. Brioschi,
  • A. Guarino,
  • S. Ghilardi,
  • L. Sandrini,
  • S. Eligini,
  • G. Polvani,
  • O. Bergman,
  • P. Eriksson,
  • E. Tremoli

DOI
https://doi.org/10.1038/s42003-021-02630-z
Journal volume & issue
Vol. 4, no. 1
pp. 1 – 17

Abstract

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Banfi et al. investigate the role of Prenylcysteine oxidase 1 (PCYOX1), an enzyme implicated in catabolism of prenylated cysteine, in human and murine atherosclerosis. They find that loss of PCYOX1 is anti-atherogenic and understanding its biology and functions can potentially provide significant therapeutic opportunities in addressing atherosclerosis.