Role of Filaggrin in Pediatric Allergology

Abstract

There had been found strong evidence that a violation of the epidermal barrier is a necessary condition for the development of sensitivity to allergens. Study of defects in the filaggrin gene is a major breakthrough in understanding the molecular and genetic mechanisms of atopic and allergic diseases. The study of filaggrin molecules and defects in filaggrin gene is important to consider further strategies for treatment of atopic dermatitis, and ultimately for preventing the development of allergic diseases.

Keywords

• allergоlogy
• children
• filaggrin