Long-Term NMDAR Antagonism Correlates Weight Loss With Less Eating

Shi-Ning Deng; Yu-Hua Yan; Tai-Lin Zhu; Bing-Ke Ma; Hui-Ran Fan; Yan-Mei Liu; Wei-Guang Li; Fei Li

doi:10.3389/fpsyt.2019.00015

Frontiers in Psychiatry (Feb 2019)

Long-Term NMDAR Antagonism Correlates Weight Loss With Less Eating

Shi-Ning Deng,
Yu-Hua Yan,
Tai-Lin Zhu,
Bing-Ke Ma,
Hui-Ran Fan,
Yan-Mei Liu,
Wei-Guang Li,
Fei Li

Affiliations

Shi-Ning Deng: Developmental and Behavioral Pediatric Department and Child Primary Care Department, Ministry of Education-Shanghai Key Laboratory of Children's Environmental Health, Shanghai Institute for Pediatric Research, Xinhua Hospital Affiliated Shanghai Jiao Tong University School of Medicine, Shanghai, China
Yu-Hua Yan: Key Laboratory of Brain Functional Genomics, Ministry of Education, East China Normal University, Shanghai, China
Tai-Lin Zhu: Key Laboratory of Brain Functional Genomics, Ministry of Education, East China Normal University, Shanghai, China
Bing-Ke Ma: Key Laboratory of Brain Functional Genomics, Ministry of Education, East China Normal University, Shanghai, China
Hui-Ran Fan: Developmental and Behavioral Pediatric Department and Child Primary Care Department, Ministry of Education-Shanghai Key Laboratory of Children's Environmental Health, Shanghai Institute for Pediatric Research, Xinhua Hospital Affiliated Shanghai Jiao Tong University School of Medicine, Shanghai, China
Yan-Mei Liu: Developmental and Behavioral Pediatric Department and Child Primary Care Department, Ministry of Education-Shanghai Key Laboratory of Children's Environmental Health, Shanghai Institute for Pediatric Research, Xinhua Hospital Affiliated Shanghai Jiao Tong University School of Medicine, Shanghai, China
Wei-Guang Li: Collaborative Innovation Center for Brain Science, Department of Anatomy and Physiology, Shanghai Jiao Tong University School of Medicine, Shanghai, China
Fei Li: Developmental and Behavioral Pediatric Department and Child Primary Care Department, Ministry of Education-Shanghai Key Laboratory of Children's Environmental Health, Shanghai Institute for Pediatric Research, Xinhua Hospital Affiliated Shanghai Jiao Tong University School of Medicine, Shanghai, China

DOI: https://doi.org/10.3389/fpsyt.2019.00015
Journal volume & issue: Vol. 10

Abstract

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Memantine hydrochloride is an uncompetitive N-methyl-D-aspartate (NMDA) antagonist for treatment of moderate-to-severe Alzheimer's disease. Several studies have shown that memantine can significantly correct the binge-like eating behavior in human and animal models. People with overeating behavior are more likely to be obese. Therefore, we suppose that memantine would be a good candidate for the treatment of obesity. In this study, memantine was shown to increase weight loss in obese mice induced by high fat diet. Memantine was shown to decrease food intake without inducing abdominal discomfort and anxiety, suggesting that this compound would be a good candidate drug for obesity control.

Published in Frontiers in Psychiatry

ISSN: 1664-0640 (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Medicine: Internal medicine: Neurosciences. Biological psychiatry. Neuropsychiatry: Neurology. Diseases of the nervous system: Psychiatry
Website: https://www.frontiersin.org/journals/psychiatry

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