Structural mechanism of TRPV3 channel inhibition by the anesthetic dyclonine

Arthur Neuberger; Kirill D. Nadezhdin; Alexander I. Sobolevsky

doi:10.1038/s41467-022-30537-8

Nature Communications (May 2022)

Structural mechanism of TRPV3 channel inhibition by the anesthetic dyclonine

Arthur Neuberger,
Kirill D. Nadezhdin,
Alexander I. Sobolevsky

Affiliations

Arthur Neuberger: Department of Biochemistry and Molecular Biophysics, Columbia University
Kirill D. Nadezhdin: Department of Biochemistry and Molecular Biophysics, Columbia University
Alexander I. Sobolevsky: Department of Biochemistry and Molecular Biophysics, Columbia University

DOI: https://doi.org/10.1038/s41467-022-30537-8
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 9

Abstract

Read online

TRPV3 mediates cutaneous sensations such as itch and pain. Here authors present the cryo-EM structure of TRPV3 bound with local anesthetic which binds the channel in membrane portals that connect the membrane environment to the channel pore.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

About the journal