Drug-seeking motivation level in male rats determines offspring susceptibility or resistance to cocaine-seeking behaviour

Qiumin Le; Biao Yan; Xiangchen Yu; Yanqing Li; Haikun Song; Huiwen Zhu; Weiqing Hou; Dingailu Ma; Feizhen Wu; Yuqing Zhou; Lan Ma

doi:10.1038/ncomms15527

Nature Communications (May 2017)

Drug-seeking motivation level in male rats determines offspring susceptibility or resistance to cocaine-seeking behaviour

Qiumin Le,
Biao Yan,
Xiangchen Yu,
Yanqing Li,
Haikun Song,
Huiwen Zhu,
Weiqing Hou,
Dingailu Ma,
Feizhen Wu,
Yuqing Zhou,
Lan Ma

Affiliations

Qiumin Le: Department of Neurosurgery, and Institute of Translational Neuroscience, Huashan Hospital, State Key Laboratory of Medical Neurobiology, School of Basic Medical Sciences and Institutes of Brain Science, Fudan University
Biao Yan: Department of Neurosurgery, and Institute of Translational Neuroscience, Huashan Hospital, State Key Laboratory of Medical Neurobiology, School of Basic Medical Sciences and Institutes of Brain Science, Fudan University
Xiangchen Yu: Department of Neurosurgery, and Institute of Translational Neuroscience, Huashan Hospital, State Key Laboratory of Medical Neurobiology, School of Basic Medical Sciences and Institutes of Brain Science, Fudan University
Yanqing Li: Department of Neurosurgery, and Institute of Translational Neuroscience, Huashan Hospital, State Key Laboratory of Medical Neurobiology, School of Basic Medical Sciences and Institutes of Brain Science, Fudan University
Haikun Song: Department of Neurosurgery, and Institute of Translational Neuroscience, Huashan Hospital, State Key Laboratory of Medical Neurobiology, School of Basic Medical Sciences and Institutes of Brain Science, Fudan University
Huiwen Zhu: Department of Neurosurgery, and Institute of Translational Neuroscience, Huashan Hospital, State Key Laboratory of Medical Neurobiology, School of Basic Medical Sciences and Institutes of Brain Science, Fudan University
Weiqing Hou: Department of Neurosurgery, and Institute of Translational Neuroscience, Huashan Hospital, State Key Laboratory of Medical Neurobiology, School of Basic Medical Sciences and Institutes of Brain Science, Fudan University
Dingailu Ma: Laboratory of Epigenetics, Institutes of Biomedical Sciences, Fudan University
Feizhen Wu: Laboratory of Epigenetics, Institutes of Biomedical Sciences, Fudan University
Yuqing Zhou: Department of Neurosurgery, and Institute of Translational Neuroscience, Huashan Hospital, State Key Laboratory of Medical Neurobiology, School of Basic Medical Sciences and Institutes of Brain Science, Fudan University
Lan Ma: Department of Neurosurgery, and Institute of Translational Neuroscience, Huashan Hospital, State Key Laboratory of Medical Neurobiology, School of Basic Medical Sciences and Institutes of Brain Science, Fudan University

DOI: https://doi.org/10.1038/ncomms15527
Journal volume & issue: Vol. 8, no. 1
pp. 1 – 13

Abstract

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Drug addiction is partially heritable but the non-genetic inheritance mechanisms are not well understood. The authors show that motivation of male rats in response to cocaine self-administration elicit susceptibility and/or decreased resistance to developing addiction like behaviour in offspring.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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