The Model of PPARγ-Downregulated Signaling in Psoriasis
Vladimir Sobolev,
Anastasia Nesterova,
Anna Soboleva,
Evgenia Dvoriankova,
Anastas Piruzyan,
Dzerassa Mildzikhova,
Irina Korsunskaya,
Oxana Svitich
Affiliations
Vladimir Sobolev
I. Mechnikov Research Institute for Vaccines and Sera RAMS, 5 Malyy Kazennyy Pereulok, 105064 Moscow, Russia
Anastasia Nesterova
Life Science Research and Development Department, Elsevier Inc., Rockville, USA
Anna Soboleva
Centre of Theoretical Problems of Physico-Chemical Pharmacology, Russian Academy of Sciences, Russian Academy of Sciences, 4 Kosygin street, 119334 Moscow, Russia
Evgenia Dvoriankova
Centre of Theoretical Problems of Physico-Chemical Pharmacology, Russian Academy of Sciences, Russian Academy of Sciences, 4 Kosygin street, 119334 Moscow, Russia
Anastas Piruzyan
Centre of Theoretical Problems of Physico-Chemical Pharmacology, Russian Academy of Sciences, Russian Academy of Sciences, 4 Kosygin street, 119334 Moscow, Russia
Dzerassa Mildzikhova
Centre of Theoretical Problems of Physico-Chemical Pharmacology, Russian Academy of Sciences, Russian Academy of Sciences, 4 Kosygin street, 119334 Moscow, Russia
Irina Korsunskaya
Centre of Theoretical Problems of Physico-Chemical Pharmacology, Russian Academy of Sciences, Russian Academy of Sciences, 4 Kosygin street, 119334 Moscow, Russia
Oxana Svitich
I. Mechnikov Research Institute for Vaccines and Sera RAMS, 5 Malyy Kazennyy Pereulok, 105064 Moscow, Russia
Interactions of genes in intersecting signaling pathways, as well as environmental influences, are required for the development of psoriasis. Peroxisome proliferator-activated receptor gamma (PPARγ) is a nuclear receptor and transcription factor which inhibits the expression of many proinflammatory genes. We tested the hypothesis that low levels of PPARγ expression promote the development of psoriatic lesions. We combined experimental results and network functional analysis to reconstruct the model of PPARγ-downregulated signaling in psoriasis. We hypothesize that the expression of IL17, STAT3, FOXP3, and RORC and FOSL1 genes in psoriatic skin is correlated with the level of PPARγ expression, and they belong to the same signaling pathway that regulates the development of psoriasis lesion.
