Untangling Traffic Jams: RAB11FIP4 Orchestrates Cellular Recovery in Cystinosis

Abstract

RAB11FIP4 (RAB11 family interacting protein 4), a RAB11A (Ras-related protein Rab-11) effector protein downregulated in cystinosis, plays a crucial role in cellular trafficking. Reconstitution of RAB11FIP4 in cystinotic cells restores multiple cellular functions, including lysosomal trafficking, autophagy, and the endoplasmic reticulum stress response. These findings identify RAB11FIP4 as both a key player in cystinosis pathogenesis and a promising therapeutic target. The purpose of this punctum is to highlight how restoring RAB11FIP4 expression rescues cellular homeostasis in cystinosis through the regulation of trafficking pathways.

Keywords

• Autophagy
• chaperone-mediated autophagy
• endocytic trafficking
• lysosomes
• RAB GTPases
• vesicular transport