Nature Communications (Aug 2022)
Specificity of TGF-β1 signal designated by LRRC33 and integrin αVβ8
Abstract
Microenvironment localization and activation of L-TGF-β1 determine its specific function. Here, the authors elucidated the underlying mechanisms of specific presentation of L-TGF-β1 on the surface of myeloid lineage cells designated by LRRC33, and its activation by integrin αVβ8.