Inactivation of KCNQ1 potassium channels reveals dynamic coupling between voltage sensing and pore opening

Panpan Hou; Jodene Eldstrom; Jingyi Shi; Ling Zhong; Kelli McFarland; Yuan Gao; David Fedida; Jianmin Cui

doi:10.1038/s41467-017-01911-8

Nature Communications (Nov 2017)

Inactivation of KCNQ1 potassium channels reveals dynamic coupling between voltage sensing and pore opening

Panpan Hou,
Jodene Eldstrom,
Jingyi Shi,
Ling Zhong,
Kelli McFarland,
Yuan Gao,
David Fedida,
Jianmin Cui

Affiliations

Panpan Hou: Department of Biomedical Engineering, Center for the Investigation of Membrane Excitability Diseases, Cardiac Bioelectricity and Arrhythmia Center, Washington University in St Louis
Jodene Eldstrom: Department of Anesthesiology, Pharmacology and Therapeutics, University of British Columbia
Jingyi Shi: Department of Biomedical Engineering, Center for the Investigation of Membrane Excitability Diseases, Cardiac Bioelectricity and Arrhythmia Center, Washington University in St Louis
Ling Zhong: Department of Biomedical Engineering, Center for the Investigation of Membrane Excitability Diseases, Cardiac Bioelectricity and Arrhythmia Center, Washington University in St Louis
Kelli McFarland: Department of Biomedical Engineering, Center for the Investigation of Membrane Excitability Diseases, Cardiac Bioelectricity and Arrhythmia Center, Washington University in St Louis
Yuan Gao: Tencent AI Lab
David Fedida: Department of Anesthesiology, Pharmacology and Therapeutics, University of British Columbia
Jianmin Cui: Department of Biomedical Engineering, Center for the Investigation of Membrane Excitability Diseases, Cardiac Bioelectricity and Arrhythmia Center, Washington University in St Louis

DOI: https://doi.org/10.1038/s41467-017-01911-8
Journal volume & issue: Vol. 8, no. 1
pp. 1 – 11

Abstract

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KCNQ1 is a voltage-gated potassium channel that is important in cardiac and epithelial function. Here the authors present a mechanism for KCNQ1 activation and inactivation in which voltage sensor activation promotes pore opening more effectively in the intermediate open state than the fully open state, generating inactivation.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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