The efficacy of assisted reproductive technologies in patients with uterine fibroids (review)

Abstract

Despite the urgency of the problem, the impact of uterine fibroids on the effectiveness of programs assisted reproductive technology (ART) remains open. The data indicate that the induction of superovulation in vitro fertilization (IVF) increases the production of factors that contribute to the proliferation of fibroids. These data may explain the link between uterine myoma and effectiveness of ART programs, as expression of the same genes associated with implantation and post-implantation embryo development. Surgical removal of large knots prior to the IVF program in most cases, is regarded as a positive prognostic factor. However, surgical treatment, in turn, has a negative impact on the fallopian tubes and peritoneal and also leads to the appearance of the scar on the uterus. This review gives an idea of the current state of the problem and can help in the development of individual approaches in patients with infertility and uterine myoma.

Keywords

• uterine fibroids
• implantation
• in vitro fertilisation
• assisted reproductive technology