Non-Human Primate Models of Enteric Viral Infections

Abstract

There is an important role non-human primates (NHP) play in biomedical research. Phylogenetic proximity of any of the NHP species to Homo sapiens assures that much better translatability of research outcomes from model studies involving human diseases can be achieved than from those generated with other pre-clinical systems. Our group and others used during past two decades NHPs in research directed towards viral and autoimmune disorders of the gastrointestinal tract. This review summarizes progress made in the area of enteric viral infections including its applicability to human disease.

Keywords

• enteric virus
• non-human primate
• virome
• macaque
• dysbiosis
• enteritis
• diarrhea
• animal model
• rotavirus
• calicivirus
• gut microbiome