Frontiers in Microbiology (Nov 2020)
A Novel, Broad-Acting Peptide Inhibitor of Double-Stranded DNA Virus Gene Expression and Replication
- Zsolt Ruzsics,
- Zsolt Ruzsics,
- Zsolt Ruzsics,
- Katja Hoffmann,
- Katja Hoffmann,
- André Riedl,
- André Riedl,
- Adalbert Krawczyk,
- Adalbert Krawczyk,
- Marek Widera,
- Marek Widera,
- Helene Sertznig,
- Leonie Schipper,
- Valeria Kapper-Falcone,
- Valeria Kapper-Falcone,
- Valeria Kapper-Falcone,
- Monika Debreczeny,
- Wolfgang Ernst,
- Reingard Grabherr,
- Hartmut Hengel,
- Hartmut Hengel,
- Hartmut Hengel,
- Hanna Harant
Affiliations
- Zsolt Ruzsics
- Institute of Virology, Medical Center-University of Freiburg, Freiburg, Germany
- Zsolt Ruzsics
- Faculty of Medicine, University of Freiburg, Freiburg, Germany
- Zsolt Ruzsics
- German Consulting Laboratory for HSV and VZV, Medical Center-University of Freiburg, Freiburg, Germany
- Katja Hoffmann
- Institute of Virology, Medical Center-University of Freiburg, Freiburg, Germany
- Katja Hoffmann
- Faculty of Medicine, University of Freiburg, Freiburg, Germany
- André Riedl
- Institute of Virology, Medical Center-University of Freiburg, Freiburg, Germany
- André Riedl
- Faculty of Medicine, University of Freiburg, Freiburg, Germany
- Adalbert Krawczyk
- Department of Infectious Diseases, West German Centre of Infectious Diseases, Universitätsmedizin Essen, University Duisburg-Essen, Essen, Germany
- Adalbert Krawczyk
- Institute for Virology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany
- Marek Widera
- Institute for Virology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany
- Marek Widera
- Institute of Medical Virology, University Hospital Frankfurt, Goethe University Frankfurt, Frankfurt, Germany
- Helene Sertznig
- Institute for Virology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany
- Leonie Schipper
- Institute for Virology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany
- Valeria Kapper-Falcone
- Institute of Virology, Medical Center-University of Freiburg, Freiburg, Germany
- Valeria Kapper-Falcone
- Faculty of Medicine, University of Freiburg, Freiburg, Germany
- Valeria Kapper-Falcone
- German Consulting Laboratory for HSV and VZV, Medical Center-University of Freiburg, Freiburg, Germany
- Monika Debreczeny
- VIBT Imaging Center, University of Natural Resources and Life Sciences, Vienna, Austria
- Wolfgang Ernst
- Department of Biotechnology, University of Natural Resources and Life Sciences, Vienna, Austria
- Reingard Grabherr
- Department of Biotechnology, University of Natural Resources and Life Sciences, Vienna, Austria
- Hartmut Hengel
- Institute of Virology, Medical Center-University of Freiburg, Freiburg, Germany
- Hartmut Hengel
- Faculty of Medicine, University of Freiburg, Freiburg, Germany
- Hartmut Hengel
- German Consulting Laboratory for HSV and VZV, Medical Center-University of Freiburg, Freiburg, Germany
- Hanna Harant
- Pivaris BioScience GmbH, Vienna, Austria
- DOI
- https://doi.org/10.3389/fmicb.2020.601555
- Journal volume & issue
-
Vol. 11
Abstract
Viral infections are a global disease burden with only a limited number of antiviral agents available. Due to newly emerging viral pathogens and increasing occurrence of drug resistance, there is a continuous need for additional therapeutic options, preferably with extended target range. In the present study, we describe a novel antiviral peptide with broad activity against several double-stranded DNA viruses. The 22-mer peptide TAT-I24 potently neutralized viruses such as herpes simplex viruses, adenovirus type 5, cytomegalovirus, vaccinia virus, and simian virus 40 in cell culture models, while being less active against RNA viruses. The peptide TAT-I24 therefore represents a novel and promising drug candidate for use against double-stranded DNA viruses.
Keywords
