Synthesis and Docking Studies of the Novel N-(2,2-Di(1H-pyrrol-2-yl)ethyl)adamantane-1-carboxamide, a Potential 11β-HSD1 Inhibitor

Salvador Gallardo-Alfonzo; Ana Lilia Ocampo-Néstor; Claudia Contreras-Celedón; Luis Chacón-García

doi:10.1155/2014/294246

Journal of Chemistry (Jan 2014)

Synthesis and Docking Studies of the Novel N-(2,2-Di(1H-pyrrol-2-yl)ethyl)adamantane-1-carboxamide, a Potential 11β-HSD1 Inhibitor

Salvador Gallardo-Alfonzo,
Ana Lilia Ocampo-Néstor,
Claudia Contreras-Celedón,
Luis Chacón-García

Affiliations

Salvador Gallardo-Alfonzo: Laboratorio de Diseño Molecular, Instituto de Investigaciones Químico Biológicas, Universidad Michoacana de San Nicolás de Hidalgo, Edificio B-1, Ciudad Universitaria, 58033 Morelia, MICH, Mexico
Ana Lilia Ocampo-Néstor: Laboratorio de Diseño Molecular, Instituto de Investigaciones Químico Biológicas, Universidad Michoacana de San Nicolás de Hidalgo, Edificio B-1, Ciudad Universitaria, 58033 Morelia, MICH, Mexico
Claudia Contreras-Celedón: Laboratorio de Diseño Molecular, Instituto de Investigaciones Químico Biológicas, Universidad Michoacana de San Nicolás de Hidalgo, Edificio B-1, Ciudad Universitaria, 58033 Morelia, MICH, Mexico
Luis Chacón-García: Laboratorio de Diseño Molecular, Instituto de Investigaciones Químico Biológicas, Universidad Michoacana de San Nicolás de Hidalgo, Edificio B-1, Ciudad Universitaria, 58033 Morelia, MICH, Mexico

DOI: https://doi.org/10.1155/2014/294246
Journal volume & issue: Vol. 2014

Abstract

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The synthesis of the novel 1-adamantyl-(N-meso-dipyrrolylmethylene)-carboxamide is described, providing a three-step, two-pot reaction. Docking studies with 11β-HSD1 revealed favorable binding interactions with the enzyme.

Published in Journal of Chemistry

ISSN: 2090-9063 (Print); 2090-9071 (Online)
Publisher: Wiley
Country of publisher: United Kingdom
LCC subjects: Science: Chemistry
Website: https://onlinelibrary.wiley.com/journal/2962

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