AAV vector-mediated in vivo reprogramming into pluripotency

Elena Senís; Lluc Mosteiro; Stefan Wilkening; Ellen Wiedtke; Ali Nowrouzi; Saira Afzal; Raffaele Fronza; Henrik Landerer; Maria Abad; Dominik Niopek; Manfred Schmidt; Manuel Serrano; Dirk Grimm

doi:10.1038/s41467-018-05059-x

Nature Communications (Jul 2018)

AAV vector-mediated in vivo reprogramming into pluripotency

Elena Senís,
Lluc Mosteiro,
Stefan Wilkening,
Ellen Wiedtke,
Ali Nowrouzi,
Saira Afzal,
Raffaele Fronza,
Henrik Landerer,
Maria Abad,
Dominik Niopek,
Manfred Schmidt,
Manuel Serrano,
Dirk Grimm

Affiliations

Elena Senís: Virus-Host Interaction Group, Department of Infectious Diseases/Virology, Heidelberg University Hospital, Cluster of Excellence CellNetworks
Lluc Mosteiro: Tumor Suppression Group, Spanish National Cancer Research Centre (CNIO)
Stefan Wilkening: Department of Translational Oncology, National Center for Tumor Diseases (NCT) and German Cancer Research Center (DKFZ)
Ellen Wiedtke: Virus-Host Interaction Group, Department of Infectious Diseases/Virology, Heidelberg University Hospital, Cluster of Excellence CellNetworks
Ali Nowrouzi: Department of Translational Oncology, National Center for Tumor Diseases (NCT) and German Cancer Research Center (DKFZ)
Saira Afzal: Department of Translational Oncology, National Center for Tumor Diseases (NCT) and German Cancer Research Center (DKFZ)
Raffaele Fronza: Department of Translational Oncology, National Center for Tumor Diseases (NCT) and German Cancer Research Center (DKFZ)
Henrik Landerer: Virus-Host Interaction Group, Department of Infectious Diseases/Virology, Heidelberg University Hospital, Cluster of Excellence CellNetworks
Maria Abad: Cellular Plasticity and Cancer Group, Vall d’Hebron Institute of Oncology (VHIO)
Dominik Niopek: BioQuant, University of Heidelberg
Manfred Schmidt: Department of Translational Oncology, National Center for Tumor Diseases (NCT) and German Cancer Research Center (DKFZ)
Manuel Serrano: Tumor Suppression Group, Spanish National Cancer Research Centre (CNIO)
Dirk Grimm: Virus-Host Interaction Group, Department of Infectious Diseases/Virology, Heidelberg University Hospital, Cluster of Excellence CellNetworks

DOI: https://doi.org/10.1038/s41467-018-05059-x
Journal volume & issue: Vol. 9, no. 1
pp. 1 – 14

Abstract

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In vivo reprogramming of somatic cells is hampered by the need for vectors to express the OKSM factors in selected organs. Here the authors report new AAV-based vectors capable of in vivo reprogramming at low doses.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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