Nature Communications (Apr 2023)

Buffering of transcription rate by mRNA half-life is a conserved feature of Rett syndrome models

  • Deivid C. Rodrigues,
  • Marat Mufteev,
  • Kyoko E. Yuki,
  • Ashrut Narula,
  • Wei Wei,
  • Alina Piekna,
  • Jiajie Liu,
  • Peter Pasceri,
  • Olivia S. Rissland,
  • Michael D. Wilson,
  • James Ellis

DOI
https://doi.org/10.1038/s41467-023-37339-6
Journal volume & issue
Vol. 14, no. 1
pp. 1 – 15

Abstract

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Rett syndrome (RTT) is a neurodevelopmental disorder caused by mutations in the transcriptional modulator MECP2. Here, the authors measured transcription rate and mRNA half-life changes in RTT patient-derived neurons to show transcription rate buffered by mRNA half-life changes.