Nature Communications (Apr 2023)
Buffering of transcription rate by mRNA half-life is a conserved feature of Rett syndrome models
Abstract
Rett syndrome (RTT) is a neurodevelopmental disorder caused by mutations in the transcriptional modulator MECP2. Here, the authors measured transcription rate and mRNA half-life changes in RTT patient-derived neurons to show transcription rate buffered by mRNA half-life changes.