International Journal of Nanomedicine (Mar 2023)
Bacteria-Driven Tumor Microenvironment-Sensitive Nanoparticles Targeting Hypoxic Regions Enhances the Chemotherapy Outcome of Lung Cancer
Abstract
Huan Shi,1,* Lan Chen,2,* Yanlin Liu,1,* Qinglian Wen,1 Sheng Lin,1 Qian Wen,1 Yun Lu,1 Jie Dai,1 Jianmei Li,1 Susu Xiao,1 Shaozhi Fu1 1Department of Oncology, the Affiliated Hospital of Southwest Medical University, Luzhou, People’s Republic of China; 2Department of Oncology, the Affiliated Traditional Chinese Medicine Hospital of Southwest Medical University, Luzhou, People’s Republic of China*These authors contributed equally to this workCorrespondence: Shaozhi Fu, Tel +86 830-3165698, Fax +86 830-3165690, Email [email protected]: Chemotherapy still plays a dominant role in cancer treatment. However, the inability of conventional chemotherapeutic drugs to reach the hypoxic zone of solid tumors significantly weakens their efficacy. Bacteria-mediated drug delivery systems can be an effective targeting strategy for improving the therapeutic outcomes in cancer. Anaerobic bacteria have the unique ability to selectively transport drug loads to the hypoxic regions of tumors.Methods: We designed a Bifidobacterium infantis (Bif)-based biohybrid (Bif@PDA-PTX-NPs) to deliver polydopamine (PDA)-coated paclitaxel nanoparticles (PTX-NPs) to tumor tissues.Results: The self-driven Bif@PDA-PTX-NPs maintained the toxicity of PTX as well as the hypoxic homing tendency of Bif. Furthermore, Bif@PDA-PTX-NPs significantly inhibited the growth of A549 xenografts in nude mice, and prolonged the survival of the tumor-bearing mice compared to the other PTX formulations without any systemic or localized toxicity.Conclusion: The Bif@PDA-PTX-NPs biohybrids provide a new therapeutic strategy for targeted chemotherapy to solid tumors.Keywords: tumor hypoxia, bifidobacterium infantis, paclitaxel, nanoparticles, lung cancer
