Nature Communications (Jul 2021)
Oncogenic cooperation between TCF7-SPI1 and NRAS(G12D) requires β-catenin activity to drive T-cell acute lymphoblastic leukemia
- Quentin Van Thillo,
- Jolien De Bie,
- Janith A. Seneviratne,
- Sofie Demeyer,
- Sofia Omari,
- Anushree Balachandran,
- Vicki Zhai,
- Wai L. Tam,
- Bram Sweron,
- Ellen Geerdens,
- Olga Gielen,
- Sarah Provost,
- Heidi Segers,
- Nancy Boeckx,
- Glenn M. Marshall,
- Belamy B. Cheung,
- Kiyotaka Isobe,
- Itaru Kato,
- Junko Takita,
- Timothy G. Amos,
- Ira W. Deveson,
- Hannah McCalmont,
- Richard B. Lock,
- Ethan P. Oxley,
- Maximilian M. Garwood,
- Ross A. Dickins,
- Anne Uyttebroeck,
- Daniel R. Carter,
- Jan Cools,
- Charles E. de Bock
Affiliations
- Quentin Van Thillo
- Department of Human Genetics, KU Leuven
- Jolien De Bie
- Department of Human Genetics, KU Leuven
- Janith A. Seneviratne
- Children’s Cancer Institute, UNSW Sydney, Lowy Cancer Research Centre
- Sofie Demeyer
- Department of Human Genetics, KU Leuven
- Sofia Omari
- Children’s Cancer Institute, UNSW Sydney, Lowy Cancer Research Centre
- Anushree Balachandran
- Children’s Cancer Institute, UNSW Sydney, Lowy Cancer Research Centre
- Vicki Zhai
- Children’s Cancer Institute, UNSW Sydney, Lowy Cancer Research Centre
- Wai L. Tam
- Technology Innovation Lab, VIB
- Bram Sweron
- Department of Human Genetics, KU Leuven
- Ellen Geerdens
- Department of Human Genetics, KU Leuven
- Olga Gielen
- Department of Human Genetics, KU Leuven
- Sarah Provost
- Department of Human Genetics, KU Leuven
- Heidi Segers
- Leuvens Kanker Instituut (LKI), KU Leuven – UZ Leuven
- Nancy Boeckx
- Department of Oncology, KU Leuven
- Glenn M. Marshall
- Children’s Cancer Institute, UNSW Sydney, Lowy Cancer Research Centre
- Belamy B. Cheung
- Children’s Cancer Institute, UNSW Sydney, Lowy Cancer Research Centre
- Kiyotaka Isobe
- Department of Pediatrics, Graduate School of Medicine, Kyoto University
- Itaru Kato
- Department of Pediatrics, Graduate School of Medicine, Kyoto University
- Junko Takita
- Department of Pediatrics, Graduate School of Medicine, Kyoto University
- Timothy G. Amos
- Kinghorn Centre for Clinical Genomics, Garvan Institute of Medical Research
- Ira W. Deveson
- Kinghorn Centre for Clinical Genomics, Garvan Institute of Medical Research
- Hannah McCalmont
- Children’s Cancer Institute, UNSW Sydney, Lowy Cancer Research Centre
- Richard B. Lock
- Children’s Cancer Institute, UNSW Sydney, Lowy Cancer Research Centre
- Ethan P. Oxley
- Australian Centre for Blood Diseases, Monash University
- Maximilian M. Garwood
- Australian Centre for Blood Diseases, Monash University
- Ross A. Dickins
- Australian Centre for Blood Diseases, Monash University
- Anne Uyttebroeck
- Leuvens Kanker Instituut (LKI), KU Leuven – UZ Leuven
- Daniel R. Carter
- Children’s Cancer Institute, UNSW Sydney, Lowy Cancer Research Centre
- Jan Cools
- Department of Human Genetics, KU Leuven
- Charles E. de Bock
- Children’s Cancer Institute, UNSW Sydney, Lowy Cancer Research Centre
- DOI
- https://doi.org/10.1038/s41467-021-24442-9
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 15
Abstract
SPI1 fusion genes in T-cell acute lymphoblastic leukemia (T-ALL) are commonly found with co-occurring NRAS mutations. Here, the authors show that the combination of these oncogenes is necessary to drive T-ALL in a murine model and that the oncogenic activity of the SPI1 fusion is dependent on β-catenin.
