Nature Communications (Nov 2022)
RasGRP1 promotes the acute inflammatory response and restricts inflammation-associated cancer cell growth
- Cong Wang,
- Xue Li,
- Binbin Xue,
- Changping Yu,
- Luoling Wang,
- Rilin Deng,
- Hui Liu,
- Zihao Chen,
- Yingdan Zhang,
- Suping Fan,
- Chaohui Zuo,
- Hungyu Sun,
- Haizhen Zhu,
- Jianli Wang,
- Songqing Tang
Affiliations
- Cong Wang
- Institute of Pathogen Biology and Immunology, Department of Pharmacy, College of Biology, Hunan Provincial Key Laboratory of Medical Virology, Hunan University
- Xue Li
- Institute of Pathogen Biology and Immunology, Department of Pharmacy, College of Biology, Hunan Provincial Key Laboratory of Medical Virology, Hunan University
- Binbin Xue
- Institute of Pathogen Biology and Immunology, Department of Pharmacy, College of Biology, Hunan Provincial Key Laboratory of Medical Virology, Hunan University
- Changping Yu
- Institute of Pathogen Biology and Immunology, Department of Pharmacy, College of Biology, Hunan Provincial Key Laboratory of Medical Virology, Hunan University
- Luoling Wang
- Institute of Pathogen Biology and Immunology, Department of Pharmacy, College of Biology, Hunan Provincial Key Laboratory of Medical Virology, Hunan University
- Rilin Deng
- Institute of Pathogen Biology and Immunology, Department of Pharmacy, College of Biology, Hunan Provincial Key Laboratory of Medical Virology, Hunan University
- Hui Liu
- Institute of Pathogen Biology and Immunology, Department of Pharmacy, College of Biology, Hunan Provincial Key Laboratory of Medical Virology, Hunan University
- Zihao Chen
- Institute of Pathogen Biology and Immunology, Department of Pharmacy, College of Biology, Hunan Provincial Key Laboratory of Medical Virology, Hunan University
- Yingdan Zhang
- Institute of Pathogen Biology and Immunology, Department of Pharmacy, College of Biology, Hunan Provincial Key Laboratory of Medical Virology, Hunan University
- Suping Fan
- Institute of Immunology, and Bone Marrow Transplantation Center of the First Affiliated Hospital, Zhejiang University School of Medicine
- Chaohui Zuo
- Department of Gastroduodenal and Pancreatic Surgery, Translational Medicine Research Center of Liver Cancer, Hunan Cancer Hospital
- Hungyu Sun
- Institute of Pathogen Biology and Immunology, Department of Pharmacy, College of Biology, Hunan Provincial Key Laboratory of Medical Virology, Hunan University
- Haizhen Zhu
- Institute of Pathogen Biology and Immunology, Department of Pharmacy, College of Biology, Hunan Provincial Key Laboratory of Medical Virology, Hunan University
- Jianli Wang
- Institute of Immunology, and Bone Marrow Transplantation Center of the First Affiliated Hospital, Zhejiang University School of Medicine
- Songqing Tang
- Institute of Pathogen Biology and Immunology, Department of Pharmacy, College of Biology, Hunan Provincial Key Laboratory of Medical Virology, Hunan University
- DOI
- https://doi.org/10.1038/s41467-022-34659-x
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 17
Abstract
IL-6 and RasGRP1 have been shown to have important functions during inflammation and cancer. Here the authors propose the protein and mRNA of RasGRP1 have opposing functions by promoting IL-6 mediated acute inflammation and inhibiting inflammation-associated cancer through mRNA and protein mechanisms respectively.
