Correlation Between Nutritional Status and Serum C-reactive Protein in Patients with Cancer Pain

Abstract

Objective To investigate the nutritional status, inflammation level and the correlation among various indicators in patients with cancer pain. Methods A total of 146 patients with cancer pain were enrolled. NRS, NRS-2002, PG-SGA, anthropometric, dietary assessment, hematology and other methods were used for pain assessment, nutrition risk screening and nutritional status assessment, and to analyze the differences and correlation among various nutritional indicators in different degree of pain. Results There were significant differences in NRS-2002, PG-SGA and CHE between the two groups of different NRS scores (P < 0.05). There were significant differences in theprealbumin (PA), albumin (ALB), hemoglobin(HGB), cholinesterase (CHE), white blood cell (WBC), neutrophil ratio (N%) and lymphocyte (LYM) between the two groups of different C-reactive protein (CRP) concentrations (P < 0.05). NRS was negatively correlated with total number of CHE, LYM and BMI (P=0.000, P=0.003, P=0.000), and positively correlated with NRS-2002 and PG-SGA (P=0.003, P=0.000). The concentration of CRP was negatively correlated with the total number of PA, ALB, CHE, HGB and LYM (P=0.000, P=0.000, P=0.000, P=0.002, P=0.004), and positively correlated with NRS-2002 and PG-SGA (P=0.020, P=0.028). Conclusion The nutritional risk and malnutrition incidence are high in patients with cancer pain. The cancer patients with higher serum C-reactive protein concentration have worse nutritional status.

Keywords

• cancer pain
• nutritional status
• c-reactive protein