Nature Communications (Aug 2020)

Interaction of the pioneer transcription factor GATA3 with nucleosomes

  • Hiroki Tanaka,
  • Yoshimasa Takizawa,
  • Motoki Takaku,
  • Daiki Kato,
  • Yusuke Kumagawa,
  • Sara A. Grimm,
  • Paul A. Wade,
  • Hitoshi Kurumizaka

DOI
https://doi.org/10.1038/s41467-020-17959-y
Journal volume & issue
Vol. 11, no. 1
pp. 1 – 10

Abstract

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GATA 3 functions as a pioneer factor during cellular reprogramming. Here the authors delineate nucleosome positioning relative to GATA3 binding motifs and describe the structure of a GATA3–nucleosome complex; providing insight into how a pioneer factor interacts with nucleosomes and catalyze their local remodelling to produce an accessible enhancer.