The Effect of Milk Thistle Extract in the Treatment of Diabetic Nephropathy

Abstract

Background: Milk thistle has antioxidative effects and may improve renal performance. Our study investigated whether Milk thistle improve renal performance in patients with type II diabetes mellitus nephropathy. Methods: In this clinical trial study, after ethics committee approval, 65 Patients with type II diabetes mellitus were enrolled into a randomized simple sampling, prospective, double-blinded study. In the case group, was gave Milk thistle and control group was given placebo. We measured urine albumin/cratinine (A/C) ratio and eGFR before and after intervention. The gathered data were analyzed by t and paired-t tests. P 0.05); but in case group, after intervention A/C ratio was worse than before it (P < 0.05). Conclusion: The results suggest that Milk thistle did not improve the renal performance in patients with type II diabetes mellitus.

Keywords

• Milk thistle
• Diabetic nephropathy
• Treatment
• Renal performance