Indian Journal of Ophthalmology (Jan 2012)
Intravitreal bevacizumab for treatment of choroidal neovascularization associated with osteogenesis imperfecta
- Pukhraj Rishi,
- Ekta Rishi,
- Anusha Venkatraman
Affiliations
- Pukhraj Rishi
- Ekta Rishi
- Anusha Venkatraman
- DOI
- https://doi.org/10.4103/0301-4738.95882
- Journal volume & issue
-
Vol. 60,
no. 3
pp. 229 – 231
Abstract
A 12-year-old girl, diagnosed of osteogenesis imperfecta, presented with sudden visual loss in the left eye. Investigations revealed an active choroidal neovascular membrane. She underwent treatment with intravitreal Bevacizumab (1.25 mg/0.05 ml). Follow-up at 1 month revealed the development of lacquer crack running through the macula, underlying the fovea. The patient received two re-treatments at 1-month intervals, following which the choroidal neovascularization (CNV) regressed completely. However, further progression of lacquer cracks was noted. At the last follow-up, 6 months following the last injection, the fundus remained stable and vision was maintained at 20/200. Considering the natural history of the disease and the increased risk of rupture of the Bruch′s membrane in such eyes, the possible complication of a lacquer crack developing must be borne in mind, before initiating treatment.
Keywords
- Plateau iris
- primary angle closure glaucoma
- prevalence
- Enucleation
- India
- indications
- trends
- Closure glaucoma
- primary angle
- scanning electron microscopy
- trabecular
- Apoptosis
- caspase-3/7
- cigarette smoke toxicant
- hydroquinone
- Blepharophimosis
- cosmetic
- functional
- single stage
- Refractive error
- rural area
- school children
- use of spectacles
- Bietti′s crystalline dystrophy
- choroidal neovascular membrane
- ranibizumab
- Blepharoptosis
- epidermal cyst
- excision
- eyelid
- AcrySof SN60T9
- cataract
- phacoemulsification
- post-keratoplasty astigmatism
- toric intraocular lens
- Magnetic resonance imaging
- optic neuritis
- sphenoid sinus mucocele
- visual evoked response
- Cartridge tip
- descemet′s tear
- intraocular Lens
- phacoemulsification
- Allergy
- cyclosporine
- vernal keratoconjunctivitis
- Endophthalmitis
- limbal relaxing incision
- nocardia
- Ivermectin
- lid laceration
- orbital myiasis
- scalp pediculosis
- Conjunctiva
- dipetalonema
- worm
- Bevacizumab
- choroidal neovascularization
- lacquer crack
- osteogenesis imperfecta