Blood Fibrinolytic Activity in Patients with Type 2 Diabetes Mellitus Associated with Hypothyroidism

Abstract

The objective of the research was to study the level of plasminogen activator inhibitor type 1 (PAI-1) in the blood serum of patients with type 2 diabetes mellitus (DM) in combination with hypothyroidism. We have observed 62 patients with type 2 DM, 32 of them had primary hypothyroidism. Control group consisted of 20 persons without carbohydrate metabolism disorders and thyroid pathology. In patients with type 2 DM, we have detected violations in the fibrinolytic system as an increase of PAI-1, whose level depends on the body mass index, waist circumference, level of glycated haemoglobin, indexes of insulin resistance, blood lipid spectrum, as well as on the presence of microalbuminuria. The presence of hypothyroidism has an additional negative impact on the parameters of carbohydrate, lipid metabolism and PAI-1 level in patients with type 2 DM.

Keywords

• type 2 diabetes mellitus
• hypothyroidism
• blood fibrinolytic activity