Minute-scale persistence of a GPCR conformation state triggered by non-cognate G protein interactions primes signaling

Tejas M. Gupte; Michael Ritt; Matthew Dysthe; Rabia U. Malik; Sivaraj Sivaramakrishnan

doi:10.1038/s41467-019-12755-9

Nature Communications (Oct 2019)

Minute-scale persistence of a GPCR conformation state triggered by non-cognate G protein interactions primes signaling

Tejas M. Gupte,
Michael Ritt,
Matthew Dysthe,
Rabia U. Malik,
Sivaraj Sivaramakrishnan

Affiliations

Tejas M. Gupte: Department of Genetics, Cell Biology, and Development, University of Minnesota, Twin-Cities
Michael Ritt: Department of Genetics, Cell Biology, and Development, University of Minnesota, Twin-Cities
Matthew Dysthe: Department of Genetics, Cell Biology, and Development, University of Minnesota, Twin-Cities
Rabia U. Malik: Department of Genetics, Cell Biology, and Development, University of Minnesota, Twin-Cities
Sivaraj Sivaramakrishnan: Department of Genetics, Cell Biology, and Development, University of Minnesota, Twin-Cities

DOI: https://doi.org/10.1038/s41467-019-12755-9
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 15

Abstract

Read online

Recent reports suggest the spatial and temporal coupling of receptor-effector interactions, with the potential to diversify downstream responses. Here authors demonstrate the temporal coupling of cognate and non-cognate G protein interactions through priming of GPCR conformation.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

About the journal