Nature Communications (May 2017)
BLISS is a versatile and quantitative method for genome-wide profiling of DNA double-strand breaks
- Winston X. Yan,
- Reza Mirzazadeh,
- Silvano Garnerone,
- David Scott,
- Martin W. Schneider,
- Tomasz Kallas,
- Joaquin Custodio,
- Erik Wernersson,
- Yinqing Li,
- Linyi Gao,
- Yana Federova,
- Bernd Zetsche,
- Feng Zhang,
- Magda Bienko,
- Nicola Crosetto
Affiliations
- Winston X. Yan
- Broad Institute of MIT and Harvard
- Reza Mirzazadeh
- Division of Translational Medicine and Chemical Biology, Department of Medical Biochemistry and Biophysics, Science for Life Laboratory, Karolinska Institutet
- Silvano Garnerone
- Division of Translational Medicine and Chemical Biology, Department of Medical Biochemistry and Biophysics, Science for Life Laboratory, Karolinska Institutet
- David Scott
- Broad Institute of MIT and Harvard
- Martin W. Schneider
- Broad Institute of MIT and Harvard
- Tomasz Kallas
- Division of Translational Medicine and Chemical Biology, Department of Medical Biochemistry and Biophysics, Science for Life Laboratory, Karolinska Institutet
- Joaquin Custodio
- Division of Translational Medicine and Chemical Biology, Department of Medical Biochemistry and Biophysics, Science for Life Laboratory, Karolinska Institutet
- Erik Wernersson
- Division of Translational Medicine and Chemical Biology, Department of Medical Biochemistry and Biophysics, Science for Life Laboratory, Karolinska Institutet
- Yinqing Li
- Broad Institute of MIT and Harvard
- Linyi Gao
- Broad Institute of MIT and Harvard
- Yana Federova
- Broad Institute of MIT and Harvard
- Bernd Zetsche
- Broad Institute of MIT and Harvard
- Feng Zhang
- Broad Institute of MIT and Harvard
- Magda Bienko
- Division of Translational Medicine and Chemical Biology, Department of Medical Biochemistry and Biophysics, Science for Life Laboratory, Karolinska Institutet
- Nicola Crosetto
- Division of Translational Medicine and Chemical Biology, Department of Medical Biochemistry and Biophysics, Science for Life Laboratory, Karolinska Institutet
- DOI
- https://doi.org/10.1038/ncomms15058
- Journal volume & issue
-
Vol. 8,
no. 1
pp. 1 – 9
Abstract
Double-strand breaks are a major DNA lesion that can occur by endogenous and exogenous processes. Here the authors present BLISS—Breaks LabellingIn Situand Sequencing—to map breaks across the genome.
