Laryngeal extra-skeletal Ewing sarcoma treated with DC-CTL immunotherapy: A case report and review of the literature

Hanrui Wang; Hanrui Wang; Jianwei Wang; Jianwei Wang; Qiang Wang; Qiang Wang; Yujuan Yang; Yujuan Yang; Jing Guo; Jing Guo; Chao Ren; Chao Ren; Chao Ren; Yakui Mou; Yakui Mou; Chuanliang Jia; Chuanliang Jia; Xicheng Song; Xicheng Song; Xicheng Song

doi:10.3389/fonc.2022.1003393

Frontiers in Oncology (Nov 2022)

Laryngeal extra-skeletal Ewing sarcoma treated with DC-CTL immunotherapy: A case report and review of the literature

Hanrui Wang,
Hanrui Wang,
Jianwei Wang,
Jianwei Wang,
Qiang Wang,
Qiang Wang,
Yujuan Yang,
Yujuan Yang,
Jing Guo,
Jing Guo,
Chao Ren,
Chao Ren,
Chao Ren,
Yakui Mou,
Yakui Mou,
Chuanliang Jia,
Chuanliang Jia,
Xicheng Song,
Xicheng Song,
Xicheng Song

Affiliations

Hanrui Wang: Department of Otorhinolaryngology, Head and Neck Surgery, Yantai Yuhuangding Hospital, Qingdao University, Yantai, China
Hanrui Wang: Shandong Provincial Clinical Research Center for Otorhinolaryngologic Diseases, Yantai, China
Jianwei Wang: Department of Otorhinolaryngology, Head and Neck Surgery, Yantai Yuhuangding Hospital, Qingdao University, Yantai, China
Jianwei Wang: Shandong Provincial Clinical Research Center for Otorhinolaryngologic Diseases, Yantai, China
Qiang Wang: Department of Otorhinolaryngology, Head and Neck Surgery, Yantai Yuhuangding Hospital, Qingdao University, Yantai, China
Qiang Wang: Shandong Provincial Clinical Research Center for Otorhinolaryngologic Diseases, Yantai, China
Yujuan Yang: Department of Otorhinolaryngology, Head and Neck Surgery, Yantai Yuhuangding Hospital, Qingdao University, Yantai, China
Yujuan Yang: Shandong Provincial Clinical Research Center for Otorhinolaryngologic Diseases, Yantai, China
Jing Guo: Department of Otorhinolaryngology, Head and Neck Surgery, Yantai Yuhuangding Hospital, Qingdao University, Yantai, China
Jing Guo: Shandong Provincial Clinical Research Center for Otorhinolaryngologic Diseases, Yantai, China
Chao Ren: Department of Otorhinolaryngology, Head and Neck Surgery, Yantai Yuhuangding Hospital, Qingdao University, Yantai, China
Chao Ren: Shandong Provincial Clinical Research Center for Otorhinolaryngologic Diseases, Yantai, China
Chao Ren: Shandong Provincial Innovation and Practice Base for Postdoctors, Yantai Yuhuangding Hospital, Yantai, China
Yakui Mou: Department of Otorhinolaryngology, Head and Neck Surgery, Yantai Yuhuangding Hospital, Qingdao University, Yantai, China
Yakui Mou: Shandong Provincial Clinical Research Center for Otorhinolaryngologic Diseases, Yantai, China
Chuanliang Jia: Department of Otorhinolaryngology, Head and Neck Surgery, Yantai Yuhuangding Hospital, Qingdao University, Yantai, China
Chuanliang Jia: Shandong Provincial Clinical Research Center for Otorhinolaryngologic Diseases, Yantai, China
Xicheng Song: Department of Otorhinolaryngology, Head and Neck Surgery, Yantai Yuhuangding Hospital, Qingdao University, Yantai, China
Xicheng Song: Shandong Provincial Clinical Research Center for Otorhinolaryngologic Diseases, Yantai, China
Xicheng Song: Shandong Provincial Innovation and Practice Base for Postdoctors, Yantai Yuhuangding Hospital, Yantai, China

DOI: https://doi.org/10.3389/fonc.2022.1003393
Journal volume & issue: Vol. 12

Abstract

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Extra-skeletal Ewing sarcoma (EES) is a rare sarcoma composed primarily of small round cells, capable of metastasizing and relapsing. Few cases of EES originating from the larynx have been reported, and no publications regarding laryngeal EES treated with dendritic cells-cytotoxic T lymphocytes (DC-CTL) immunotherapy have been found. We described a 29-year-old woman with a mass found in the larynx. Diffuse small round cells with scanty cytoplasm shown by histology test and extremely positive staining of CD99 revealed by immunohistochemistry helped determine the diagnosis of laryngeal EES. The patient survived for seven years with no signs of recurrence or metastasis after six cycles of DC-CTL immunotherapy based on traditional treatments. This case indicates that DC-CTL immunotherapy could be considered a new option for treating EES.

Published in Frontiers in Oncology

ISSN: 2234-943X (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Medicine: Internal medicine: Neoplasms. Tumors. Oncology. Including cancer and carcinogens
Website: https://www.frontiersin.org/journals/oncology/

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