Ultrasonic-assisted unusual four-component synthesis of 7-azolylamino-4,5,6,7-tetrahydroazolo[1,5-a]pyrimidines

Abstract

Four-component reactions of 3-amino-1,2,4-triazole or 5-amino-1H-pyrazole-4-carbonitrile with aromatic aldehydes and pyruvic acid or its esters under ultrasonication were studied. Unusual for such a reaction type, a cascade of elementary stages led to the formation of 7-azolylaminotetrahydroazolo[1,5-a]pyrimidines.

Keywords

• 5-amino-1h-pyrazole-4-carbonitrile
• 3-amino-1,2,4-triazole
• 7-azolylaminotetrahydroazolo[1,5-a]pyrimidines
• heterocycle
• multicomponent reaction
• ultrasonication