Nature Communications (Jun 2021)

Super-resolution label-free volumetric vibrational imaging

  • Chenxi Qian,
  • Kun Miao,
  • Li-En Lin,
  • Xinhong Chen,
  • Jiajun Du,
  • Lu Wei

DOI
https://doi.org/10.1038/s41467-021-23951-x
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 10

Abstract

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Super-resolution microscopy is often limited by photobleaching or uneven distribution of fluorophores. The authors present a label-free superresolution method termed VISTA, combining sample-expansion and vibrational imaging, with resolution down to 78 nm in protein-rich biological structures in cells and tissues.