Nature Communications (Oct 2022)
Interleukin-22 regulates neutrophil recruitment in ulcerative colitis and is associated with resistance to ustekinumab therapy
- Polychronis Pavlidis,
- Anastasia Tsakmaki,
- Eirini Pantazi,
- Katherine Li,
- Domenico Cozzetto,
- Jonathan Digby- Bell,
- Feifei Yang,
- Jonathan W. Lo,
- Elena Alberts,
- Ana Caroline Costa Sa,
- Umar Niazi,
- Joshua Friedman,
- Anna K. Long,
- Yuchun Ding,
- Christopher D. Carey,
- Christopher Lamb,
- Mansoor Saqi,
- Matthew Madgwick,
- Leila Gul,
- Agatha Treveil,
- Tamas Korcsmaros,
- Thomas T. Macdonald,
- Graham M. Lord,
- Gavin Bewick,
- Nick Powell
Affiliations
- Polychronis Pavlidis
- School of Immunology and Microbial Sciences, King’s College London
- Anastasia Tsakmaki
- Diabetes Research Group, School of Life Course Sciences, Faculty of Life Science and Medicine, King’s College London
- Eirini Pantazi
- School of Immunology and Microbial Sciences, King’s College London
- Katherine Li
- Janssen Research & Development
- Domenico Cozzetto
- Translational Bioinformatics, National Institute for Health Research Biomedical Centre, Guy’s and St Thomas’ NHS Foundation Trust and King’s College London
- Jonathan Digby- Bell
- School of Immunology and Microbial Sciences, King’s College London
- Feifei Yang
- Janssen Research & Development
- Jonathan W. Lo
- Division of Digestive Diseases, Faculty of Medicine, Imperial College London
- Elena Alberts
- School of Immunology and Microbial Sciences, King’s College London
- Ana Caroline Costa Sa
- Janssen Research & Development
- Umar Niazi
- Translational Bioinformatics, National Institute for Health Research Biomedical Centre, Guy’s and St Thomas’ NHS Foundation Trust and King’s College London
- Joshua Friedman
- Janssen Research & Development
- Anna K. Long
- Newcastle upon Tyne Hospitals NHS Foundation Trust
- Yuchun Ding
- Translational and Clinical Research Institute, Newcastle University
- Christopher D. Carey
- Newcastle upon Tyne Hospitals NHS Foundation Trust
- Christopher Lamb
- Newcastle upon Tyne Hospitals NHS Foundation Trust
- Mansoor Saqi
- Translational Bioinformatics, National Institute for Health Research Biomedical Centre, Guy’s and St Thomas’ NHS Foundation Trust and King’s College London
- Matthew Madgwick
- Earlham Institute, Norwich Research Park
- Leila Gul
- Division of Digestive Diseases, Faculty of Medicine, Imperial College London
- Agatha Treveil
- Earlham Institute, Norwich Research Park
- Tamas Korcsmaros
- Division of Digestive Diseases, Faculty of Medicine, Imperial College London
- Thomas T. Macdonald
- Centre for Immunobiology, Barts and the London School of Medicine and Dentistry, QMUL
- Graham M. Lord
- School of Immunology and Microbial Sciences, King’s College London
- Gavin Bewick
- Diabetes Research Group, School of Life Course Sciences, Faculty of Life Science and Medicine, King’s College London
- Nick Powell
- Division of Digestive Diseases, Faculty of Medicine, Imperial College London
- DOI
- https://doi.org/10.1038/s41467-022-33331-8
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 17
Abstract
Mechanisms of non-response to ustekinumab, a biologic targeting IL-23, are currently unclear. Here, the authors show that the transcriptional program regulated by IL-22, an IL-23 responsive cytokine, is enriched in patients with ulcerative colitis unresponsive to ustekinumab and associated with higher colon neutrophil recruitment and activation of upstream IL-22 regulators.
