Obesity in western Iraqi patients: the involvement of glutathione peroxidase, catalase, superoxide dismutase, and malondialdehyde

Abstract

Abstract In this study, the relationship between obesity and antioxidant enzymes such as superoxide dismutase (SOD), glutathione, and catalase, as well as oxidative stress marker malondialdehyde (MDA) was investigated. The results showed no significant change in SOD serum levels in obese groups compared to healthy groups. However, glutathione and catalase levels were found to be significantly lower in obese individuals. Studies have suggested that reduced glutathione and catalase activity may be associated with insulin resistance and other metabolic abnormalities commonly seen in obesity. In contrast, the current research found no significant correlation between MDA levels and obesity, although some studies have reported a positive correlation between them. Further research is needed to better understand the underlying mechanisms and to investigate potential interventions targeting oxidative stress in the prevention and management of obesity. Keywords: Glutathione peroxidase, catalase, SOD, MDA, Obesity, antioxidants, oxidants.