Nature Communications (May 2021)

Structural basis of substrate recognition and thermal protection by a small heat shock protein

  • Chuanyang Yu,
  • Stephen King Pong Leung,
  • Wenxin Zhang,
  • Louis Tung Faat Lai,
  • Ying Ki Chan,
  • Man Chit Wong,
  • Samir Benlekbir,
  • Yong Cui,
  • Liwen Jiang,
  • Wilson Chun Yu Lau

DOI
https://doi.org/10.1038/s41467-021-23338-y
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 11

Abstract

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Structural insights into the small heat shock proteins (sHsps) complexes with their substrates are sparse. Here, cryo-EM structure of a plastid sHsp, Hsp21, in complex with a bona fide substrate 1-deoxy-D-xylulose 5-phosphate synthase (DXPS), suggests the anti-aggregation mechanism employed by sHsps.