Laser interstitial thermal therapy for the treatment of epilepsy: evidence to date

Abstract

Navika D Shukla, Allen L Ho, Arjun V Pendharkar, Eric S Sussman, Casey H Halpern Department of Neurosurgery, Stanford University, Stanford, CA, USA Abstract: Medically intractable epilepsy is associated with increased morbidity and mortality. For those with focal epilepsy and correlated electrophysiological or radiographic features, open surgical resection can achieve high rates of seizure control, but can be associated with neurologic deficits and cognitive effects. Recent innovations have allowed for more minimally invasive methods of surgical seizure control such as magnetic resonance-guided laser interstitial therapy (MRgLITT). MRgLITT achieves the goal of ablating seizure foci while preserving neuropsychological function and offering real-time feedback and monitoring of tissue ablation. This review summarizes the utilization of MRgLITT for mesial temporal lobe epilepsy and other seizure disorders. Overall, the efficacy of MRgLITT is comparable to that of open surgery and offers a less invasive approach in patients with significantly less morbidity. Keywords: laser ablation, MRgLITT, mesial temporal lobe epilepsy, epilepsy surgery, corpus callostomy

Keywords

• laser ablation
• MRgLITT
• mesial temporal lobe epilepsy
• epilepsy surgery
• corpus callostomy