Annals of Medicine (Dec 2025)

Growing attention of immunogenicity among patients with autoimmune diseases post-SARS-CoV-2 vaccination: meta-analysis and systematic reviews of the current studies

  • Chao Zhang,
  • Yu-Qiang Zhang,
  • Run-Ben Liu,
  • Yu-Tong Ma,
  • Lin-Kang Zhao,
  • Fu-Qiang Yin,
  • Jing Tu,
  • Yang-Yang Yao

DOI
https://doi.org/10.1080/07853890.2025.2478319
Journal volume & issue
Vol. 57, no. 1

Abstract

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Objective This study aimed to identify the optimal strategy for patients with autoimmune diseases by comparing the immunoreaction and effectiveness of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccines between healthy individuals and patients.Methods The PubMed, Embase, and Cochrane Library were searched for eligible studies on effectiveness and immunoreaction to SARS-CoV-2 vaccines in patients with autoimmune diseases published until October 07, 2022. The quality of each included study was evaluated by independent reviewers using National Institutes of Health study quality assessment tool, and the STATA 15.0 software was used for all statistical analyses.Results A total of 84 publications were included and analyzed in this meta-analysis, favoring healthy controls regarding serological response (risk ratio, RR=0.88, 95% CI (confidence interval): 0.86–0.91), antibody response (RR=0.90, 95%CI: 0.87–0.94), and incidence of seropositive immunoglobulin G (IgG) (RR=0.74, 95%CI: 0.69–0.80) than patients post-vaccination. Patients with autoimmune diseases developed lower IgG (standard mean difference, SMD=−0.64 95%CI: −0.84 to −0.43) and antibody titer level (SMD=−1.39, 95%CI: −2.30 to −0.49) than healthy individuals in AU/ml. Stratified analyses were conducted further according to various potential factors in full-text studies.Conclusion Patients who are immunocompromised and received more vaccines demonstrated poorer humoral responses and seropositive incidence after SARS-CoV-2 vaccination than healthy individuals. Despite the lack of observable favor for patients with autoimmune diseases, the trend of effectiveness of SARS-CoV-2 vaccines is close to that for healthy populations. Patients who are immunocompromised should be provided a better SARS-CoV-2 vaccination schedule, considering various vaccine subtypes, dose(s), variants of concern, and immunoassays.

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