Synthesis of aromatic glycoconjugates. Building blocks for the construction of combinatorial glycopeptide libraries

Abstract

New aromatic glycoconjugate building blocks based on the trifunctional 3-aminomethyl-5-aminobenzoic acid backbone and sugars linked to the backbone by a malonyl moiety were prepared via peptide coupling. The orthogonally protected glycoconjugates, bearing an acetyl-protected glycoside, were converted into their corresponding acids which are suitable building blocks for combinatorial glycopeptide synthesis.

Keywords

• amino acids
• aniline
• carbohydrates
• glycoconjugates
• glycopeptides