Experimental antithrombotic effect of medicinal plants: A critical review

Abstract

Thrombosis is one of the major causes of morbidity and mortality in a wide range of cardiovascular disorders (CVDs). CVDs are listed among top ten killer diseases. Antithrombotic drugs reduce the incidence of cardiovascular events about 20%–25% in people. Due to the high prevalence of thrombotic disorders, researches are being carried out on novel antithrombotic agents with minimal adverse effects in which herbal drugs are considered as alternative remedy. Medicinal plants have been used for the management of ailments since ancient times. The objective of this study is to do documentations the effect of herbal drugs on antithrombotic therapy. Herbal remedies are used to treat a large variety of thrombotic disorders. However, a number of herbal preparations have been reported to cause variations in clotting time, bleeding time, prothrombin time, activated partial thromboplastin time, thrombin time, fibrinogen, D-dimer, protein C, TXA2, etc. This is mainly by disruption of the coagulation cascade and platelet plug formation. This review can help to design future researches for antithrombotic drugs discovery with more effectiveness and safety. The reported antithrombotic drugs have the potential of improving quality of life while avoiding the side effects of conventional treatment. Data were collected by existing article on antithrombotic studies from various search engines. This review is focused on plants like Syzygium cumini L. Morus alba L., Zingiber officinal Roscoe, Allium cepa L., Nigella sativa L., Punica granatum L., Mentha longifolia L., Allium sativa L., Boswellia serrate Roxb. and Sesamum indicum L.

Keywords

• anticoagulant
• antiplatelet
• antithrombotic experimental model
• fibrinolytic
• medicinal plants
• traditional herbs