Genome-wide association study on coordination and agility in 461 Chinese Han males
Yan Wang,
He Li,
Lei Hou,
Shan Wang,
Xia Kang,
Jihong Yu,
Fenfen Tian,
Wenfeng Ni,
Xiaoyu Deng,
Tianzi Liu,
Yanqin You,
Wei Chen
Affiliations
Yan Wang
Clinical Biobank Center, Medical Innovation Research Division, Chinese PLA General Hospital, Beijing, China; Corresponding author.
He Li
Beijing Institute of Genomics (China National Center for Bioinformation), Chinese Academy of Sciences, Beijing, China
Lei Hou
Department of Neurology, The First Medical Center, Chinese PLA General Hospital, Beijing, China
Shan Wang
Clinical Biobank Center, Medical Innovation Research Division, Chinese PLA General Hospital, Beijing, China
Xia Kang
Clinical Biobank Center, Medical Innovation Research Division, Chinese PLA General Hospital, Beijing, China
Jihong Yu
Clinical Biobank Center, Medical Innovation Research Division, Chinese PLA General Hospital, Beijing, China
Fenfen Tian
Clinical Biobank Center, Medical Innovation Research Division, Chinese PLA General Hospital, Beijing, China
Wenfeng Ni
Clinical Biobank Center, Medical Innovation Research Division, Chinese PLA General Hospital, Beijing, China
Xiaoyu Deng
Beijing Advanced Innovation Centre for Biomedical Engineering, Key Laboratory for Biomechanics and Mechanobiology of Ministry of Education, School of Engineering Medicine, Beihang University, Beijing, China
Tianzi Liu
Beijing Institute of Genomics (China National Center for Bioinformation), Chinese Academy of Sciences, Beijing, China
Yanqin You
Department of Obstetrics and Gynecology, The First Medical Center, Chinese PLA General Hospital, Beijing, China; Corresponding author.
Wei Chen
Beijing Advanced Innovation Centre for Biomedical Engineering, Key Laboratory for Biomechanics and Mechanobiology of Ministry of Education, School of Engineering Medicine, Beihang University, Beijing, China; State Key Laboratory of Ophthalmology, Optometry and Vision Science, Wenzhou Medical University, Wenzhou, China; Corresponding author. Beijing Advanced Innovation Centre for Biomedical Engineering, Key Laboratory for Biomechanics and Mechanobiology of Ministry of Education, School of Engineering Medicine, Beihang University, Beijing, China.
Purpose: There is growing evidence that genetic factors can influence human athletic performance. In many sports performances, excellent coordination and agility are the keys to mastery. However, few studies have been devoted to identifying genetic influences on athletic performance. Methods: We generated a derived measure of coordination and agility from the data of hexagonal jumps and T-runs and conducted genome-wide association and meta-analysis studies focused on coordination and agility. Results: The phenotypic correlation and genetic covariance analysis indicated that hexagonal jumps and T-runs were possibly influenced by the same set of genetic factors (R = 0.27, genetic covariance = 0.59). Meta-analysis identified rs117047321 genome-wide significant association (N = 143, P < 10E-5) with coordination and agility, and this association was replicated in the replication group (N = 318, P < 0.05). The CG genotype samples of this single nucleotide polymorphism (SNP) required a longer average movement time than the CC genotype samples, and the CG genotype only exists in Asia, which may belong to the East Asia-specific variation. This SNP is located on MYO5B, which is highly expressed in tissues such as the brain, heart, and muscle, suggesting that this locus might be a genetic factor related to human energy metabolism. Conclusion: Our study indicated that genetic factors can affect the athletic performance of coordination and agility. These findings may provide valuable insights for using genetic factors to evaluate sports characteristics.
