Nature Communications (Apr 2021)
Chromosome Xq23 is associated with lower atherogenic lipid concentrations and favorable cardiometabolic indices
- Pradeep Natarajan,
- Akhil Pampana,
- Sarah E. Graham,
- Sanni E. Ruotsalainen,
- James A. Perry,
- Paul S. de Vries,
- Jai G. Broome,
- James P. Pirruccello,
- Michael C. Honigberg,
- Krishna Aragam,
- Brooke Wolford,
- Jennifer A. Brody,
- Lucinda Antonacci-Fulton,
- Moscati Arden,
- Stella Aslibekyan,
- Themistocles L. Assimes,
- Christie M. Ballantyne,
- Lawrence F. Bielak,
- Joshua C. Bis,
- Brian E. Cade,
- Ron Do,
- Harsha Doddapaneni,
- Leslie S. Emery,
- Yi-Jen Hung,
- Marguerite R. Irvin,
- Alyna T. Khan,
- Leslie Lange,
- Jiwon Lee,
- Rozenn N. Lemaitre,
- Lisa W. Martin,
- Ginger Metcalf,
- May E. Montasser,
- Jee-Young Moon,
- Donna Muzny,
- Jeffrey R. O’Connell,
- Nicholette D. Palmer,
- Juan M. Peralta,
- Patricia A. Peyser,
- Adrienne M. Stilp,
- Michael Tsai,
- Fei Fei Wang,
- Daniel E. Weeks,
- Lisa R. Yanek,
- James G. Wilson,
- Goncalo Abecasis,
- Donna K. Arnett,
- Lewis C. Becker,
- John Blangero,
- Eric Boerwinkle,
- Donald W. Bowden,
- Yi-Cheng Chang,
- Yii-Der I. Chen,
- Won Jung Choi,
- Adolfo Correa,
- Joanne E. Curran,
- Mark J. Daly,
- Susan K. Dutcher,
- Patrick T. Ellinor,
- Myriam Fornage,
- Barry I. Freedman,
- Stacey Gabriel,
- Soren Germer,
- Richard A. Gibbs,
- Jiang He,
- Kristian Hveem,
- Gail P. Jarvik,
- Robert C. Kaplan,
- Sharon L. R. Kardia,
- Eimear Kenny,
- Ryan W. Kim,
- Charles Kooperberg,
- Cathy C. Laurie,
- Seonwook Lee,
- Don M. Lloyd-Jones,
- Ruth J. F. Loos,
- Steven A. Lubitz,
- Rasika A. Mathias,
- Karine A. Viaud Martinez,
- Stephen T. McGarvey,
- Braxton D. Mitchell,
- Deborah A. Nickerson,
- Kari E. North,
- Aarno Palotie,
- Cheol Joo Park,
- Bruce M. Psaty,
- D. C. Rao,
- Susan Redline,
- Alexander P. Reiner,
- Daekwan Seo,
- Jeong-Sun Seo,
- Albert V. Smith,
- Russell P. Tracy,
- Ramachandran S. Vasan,
- Sekar Kathiresan,
- L. Adrienne Cupples,
- Jerome I. Rotter,
- Alanna C. Morrison,
- Stephen S. Rich,
- Samuli Ripatti,
- Cristen Willer,
- NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium,
- FinnGen,
- Gina M. Peloso
Affiliations
- Pradeep Natarajan
- Cardiovascular Research Center, Massachusetts General Hospital
- Akhil Pampana
- Cardiovascular Research Center, Massachusetts General Hospital
- Sarah E. Graham
- Department of Internal Medicine: Cardiology, University of Michigan
- Sanni E. Ruotsalainen
- Institute for Molecular Medicine Finland, University of Helsinki
- James A. Perry
- University of Maryland School of Medicine, Division of Endocrinology, Diabetes and Nutrition and Program for Personalized and Genomic Medicine
- Paul S. de Vries
- Human Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston
- Jai G. Broome
- Department of Biostatistics, University of Washington
- James P. Pirruccello
- Cardiovascular Research Center, Massachusetts General Hospital
- Michael C. Honigberg
- Cardiovascular Research Center, Massachusetts General Hospital
- Krishna Aragam
- Cardiovascular Research Center, Massachusetts General Hospital
- Brooke Wolford
- Department of Computational Medicine and Bioinformatics, University of Michigan
- Jennifer A. Brody
- Cardiovascular Health Research Unit, Department of Medicine, University of Washington
- Lucinda Antonacci-Fulton
- The McDonnell Genome Institute, Washington University School of Medicine
- Moscati Arden
- The Charles Bronfman Institute for Personalized Medicine, Ichan School of Medicine at Mount Sinai
- Stella Aslibekyan
- Department of Epidemiology, School of Public Health, University of Alabama at Birmingham
- Themistocles L. Assimes
- Department of Medicine, Stanford University School of Medicine
- Christie M. Ballantyne
- Section of Cardiovascular Research, Baylor College of Medicine
- Lawrence F. Bielak
- Department of Epidemiology, School of Public Health, University of Michigan
- Joshua C. Bis
- Cardiovascular Health Research Unit, Department of Medicine, University of Washington
- Brian E. Cade
- Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School
- Ron Do
- The Charles Bronfman Institute for Personalized Medicine, Ichan School of Medicine at Mount Sinai
- Harsha Doddapaneni
- Human Genome Sequencing Center, Baylor College of Medicine
- Leslie S. Emery
- Department of Biostatistics, University of Washington
- Yi-Jen Hung
- Division of Endocrine and Metabolism, Tri-Service General Hospital Songshan branch
- Marguerite R. Irvin
- Department of Epidemiology, School of Public Health, University of Alabama at Birmingham
- Alyna T. Khan
- Department of Biostatistics, University of Washington
- Leslie Lange
- Division of Biomedical Informatics and Personalized Medicine, Department of Medicine, University of Colorado Anschutz Medical Campus
- Jiwon Lee
- Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School
- Rozenn N. Lemaitre
- Cardiovascular Health Research Unit, Department of Medicine, University of Washington
- Lisa W. Martin
- Division of Cardiology, George Washington University School of Medicine and Healthcare Sciences
- Ginger Metcalf
- Human Genome Sequencing Center, Baylor College of Medicine
- May E. Montasser
- University of Maryland School of Medicine, Division of Endocrinology, Diabetes and Nutrition and Program for Personalized and Genomic Medicine
- Jee-Young Moon
- Department of Epidemiology and Population Health, Albert Einstein College of Medicine
- Donna Muzny
- Human Genome Sequencing Center, Baylor College of Medicine
- Jeffrey R. O’Connell
- University of Maryland School of Medicine, Division of Endocrinology, Diabetes and Nutrition and Program for Personalized and Genomic Medicine
- Nicholette D. Palmer
- Department of Biochemistry, Wake Forest School of Medicine
- Juan M. Peralta
- Department of Human Genetics and South Texas Diabetes and Obesity Institute, University of Texas Rio Grande Valley School of Medicine
- Patricia A. Peyser
- Department of Epidemiology, School of Public Health, University of Michigan
- Adrienne M. Stilp
- Department of Biostatistics, University of Washington
- Michael Tsai
- Department of Laboratory Medicine and Pathology, University of Minnesota
- Fei Fei Wang
- Department of Biostatistics, University of Washington
- Daniel E. Weeks
- Departments of Human Genetics and Biostatistics, University of Pittsburgh, Pittsburgh
- Lisa R. Yanek
- Department of Medicine, Johns Hopkins University School of Medicine
- James G. Wilson
- Division of Cardiovascular Medicine, Beth Israel Deaconess Medical Center
- Goncalo Abecasis
- Department of Biostatistics, University of Michigan
- Donna K. Arnett
- Deans office, School of Public Health, University of Kentucky
- Lewis C. Becker
- Department of Medicine, Johns Hopkins University School of Medicine
- John Blangero
- Department of Human Genetics and South Texas Diabetes and Obesity Institute, University of Texas Rio Grande Valley School of Medicine
- Eric Boerwinkle
- Human Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston
- Donald W. Bowden
- Department of Biochemistry, Wake Forest School of Medicine
- Yi-Cheng Chang
- Department of Internal Medicine, National Taiwan University Hospital
- Yii-Der I. Chen
- The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center
- Won Jung Choi
- Psomagen. Inc. (formerly Macrogen USA)
- Adolfo Correa
- Department of Medicine, University of Mississippi Medical Center
- Joanne E. Curran
- Department of Human Genetics and South Texas Diabetes and Obesity Institute, University of Texas Rio Grande Valley School of Medicine
- Mark J. Daly
- Program in Medical and Population Genetics, Broad Institute
- Susan K. Dutcher
- The McDonnell Genome Institute, Washington University School of Medicine
- Patrick T. Ellinor
- Program in Medical and Population Genetics, Broad Institute
- Myriam Fornage
- Institute of Molecular Medicine, the University of Texas Health Science Center at Houston
- Barry I. Freedman
- Department of Internal Medicine, Section on Nephrology, Wake Forest School of Medicine, Winston-
- Stacey Gabriel
- Genomics Platform, Broad Institute of Harvard and MIT
- Soren Germer
- New York Genome Center
- Richard A. Gibbs
- Human Genome Sequencing Center, Baylor College of Medicine
- Jiang He
- Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine, and Tulane University Translational Science Institute, Tulane University
- Kristian Hveem
- Department of Public Health and General Practice, HUNT Research Centre, Norwegian University of Science and Technology
- Gail P. Jarvik
- Departments of Medicine (Medical Genetics) and Genome Sciences, University of Washington
- Robert C. Kaplan
- Department of Epidemiology and Population Health, Albert Einstein College of Medicine
- Sharon L. R. Kardia
- Department of Epidemiology, School of Public Health, University of Michigan
- Eimear Kenny
- The Charles Bronfman Institute for Personalized Medicine, Ichan School of Medicine at Mount Sinai
- Ryan W. Kim
- Psomagen. Inc. (formerly Macrogen USA)
- Charles Kooperberg
- Division of Public Health Sciences, Fred Hutchinson Cancer Research Center
- Cathy C. Laurie
- Department of Biostatistics, University of Washington
- Seonwook Lee
- Psomagen. Inc. (formerly Macrogen USA)
- Don M. Lloyd-Jones
- Preventive Medicine, Feinberg School of Medicine, Northwestern University
- Ruth J. F. Loos
- The Charles Bronfman Institute for Personalized Medicine, Ichan School of Medicine at Mount Sinai
- Steven A. Lubitz
- Cardiac Arrhythmia Service and Cardiovascular Research Center Massachusetts General Hospital
- Rasika A. Mathias
- Department of Medicine, Johns Hopkins University School of Medicine
- Karine A. Viaud Martinez
- Illumina Laboratory Services, Illumina inc.
- Stephen T. McGarvey
- Department of Epidemiology and International Health Institute, Brown University
- Braxton D. Mitchell
- University of Maryland School of Medicine, Division of Endocrinology, Diabetes and Nutrition and Program for Personalized and Genomic Medicine
- Deborah A. Nickerson
- Department of Genome Sciences, University of Washington
- Kari E. North
- Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill
- Aarno Palotie
- Program in Medical and Population Genetics, Broad Institute
- Cheol Joo Park
- Psomagen. Inc. (formerly Macrogen USA)
- Bruce M. Psaty
- Cardiovascular Health Research Unit, Department of Medicine, University of Washington
- D. C. Rao
- Division of Biostatistics, Washington University School of Medicine
- Susan Redline
- Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School
- Alexander P. Reiner
- Division of Public Health Sciences, Fred Hutchinson Cancer Research Center
- Daekwan Seo
- Psomagen. Inc. (formerly Macrogen USA)
- Jeong-Sun Seo
- Psomagen. Inc. (formerly Macrogen USA)
- Albert V. Smith
- Department of Biostatistics, University of Michigan
- Russell P. Tracy
- Departments of Pathology & Laboratory Medicine and Biochemistry, Larrner College of Medicine, University of Vermont
- Ramachandran S. Vasan
- Sections of Preventive Medicine and Epidemiology and Cardiology, Department of Medicine, Boston University School of Medicine
- Sekar Kathiresan
- Program in Medical and Population Genetics, Broad Institute
- L. Adrienne Cupples
- NHLBI Framingham Heart Study
- Jerome I. Rotter
- The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center
- Alanna C. Morrison
- Human Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston
- Stephen S. Rich
- Center for Public Health Genomics, University of Virginia
- Samuli Ripatti
- Program in Medical and Population Genetics, Broad Institute
- Cristen Willer
- Department of Internal Medicine: Cardiology, University of Michigan
- NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium
- FinnGen
- Gina M. Peloso
- Department of Biostatistics, Boston University School of Public Health
- DOI
- https://doi.org/10.1038/s41467-021-22339-1
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 14
Abstract
The influence of X chromosome genetic variation on blood lipids and coronary heart disease (CHD) is not well understood. Here, the authors analyse X chromosome sequencing data across 65,322 multi-ancestry individuals, identifying associations of the Xq23 locus with lipid changes and reduced risk of CHD and diabetes mellitus.
