Lipid Metabolism as a Potential Target of Liver Cancer

Abstract

Kangze Wu, Feizhuan Lin Department of Hepatobiliary Surgery, Shaoxing People’s Hospital, Shaoxing, People’s Republic of ChinaCorrespondence: Feizhuan Lin, Department of Hepatobiliary Surgery, Shaoxing People’s Hospital, Shaoxing, People’s Republic of China, Email [email protected]: Hepatocellular carcinoma (HCC) stands as a severe malignant tumor with a profound impact on overall health, often accompanied by an unfavorable prognosis. Despite some advancements in the diagnosis and treatment of this disease, improving the prognosis of HCC remains a formidable challenge. It is noteworthy that lipid metabolism plays a pivotal role in the onset, development, and progression of tumor cells. Existing research indicates the potential application of targeting lipid metabolism in the treatment of HCC. This review aims to thoroughly explore the alterations in lipid metabolism in HCC, offering a detailed account of the potential advantages associated with innovative therapeutic strategies targeting lipid metabolism. Targeting lipid metabolism holds promise for potentially enhancing the prognosis of HCC.Keywords: cholesterol, fatty acid, hepatocellular carcinoma, lipid uptake, lipid catabolism, lipid synthesis

Keywords

• cholesterol
• fatty acid
• hepatocellular carcinoma
• lipid uptake
• lipid catabolism
• lipid synthesis